Kryzhanovskiĭ G N, Morrison V V
Biull Eksp Biol Med. 1987 Nov;104(11):543-5.
The study of survival and life span of mice and white rats upon the administration of LD50 of the toxin has shown that an antihypoxic agent--gutimine (50-200 mg/kg)--had a protecting effect in type C botulinum intoxication. A combined use of gutimine and 4-aminopyridine (1-5 mg/kg), facilitating a transmitter release in synapses, had a more marked protecting effect in botulinum intoxication. Due to the potentiation of the drugs effect during their combined application, the doses of each drug in the combination could be reduced.
对给予毒素半数致死量（LD50）的小鼠和大白鼠的存活及寿命研究表明，抗缺氧剂古替明（50 - 200毫克/千克）在C型肉毒中毒中具有保护作用。古替明与促进突触中递质释放的4 - 氨基吡啶（1 - 5毫克/千克）联合使用，在肉毒中毒中具有更显著的保护作用。由于联合应用时药物作用的增强，联合用药中每种药物的剂量可以减少。
