Morrison V V, Kryzhanovskiĭ G N
Biull Eksp Biol Med. 1985 Oct;100(10):445-7.
The studies of survival and the life span of mice and the toxin in LD50 have shown that 4-aminopyridine (4-AP) at doses of 1, 2 and 5 mg/kg has a therapeutic effect on type C botulinic intoxication. Maximum protective effect is observed when 4-AP at a dose of 2 mg/kg is injected twice daily. Therefore, 4-AP, enhancing the transmitter release into cholinergic synapses, weakens the toxic effect of botulinic toxin.
对小鼠存活率、寿命以及LD50中毒素的研究表明，剂量为1、2和5mg/kg的4-氨基吡啶（4-AP）对C型肉毒中毒具有治疗作用。当每天注射两次剂量为2mg/kg的4-AP时，可观察到最大保护作用。因此，4-AP通过增强向胆碱能突触的递质释放，减弱了肉毒毒素的毒性作用。
