Tape Christopher J
The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.
Trends Cancer. 2017 Feb;3(2):79-88. doi: 10.1016/j.trecan.2016.12.004.
Tissues contain multiple different cell types and can be considered to be heterocellular systems. Signaling between different cells allows tissues to achieve phenotypes that no cell type can achieve in isolation. Such emergent tissue-level phenotypes can be said to 'supervene upon' heterocellular signaling. It is proposed here that cancer is also an emergent phenotype that supervenes upon heterocellular signaling. Using colorectal cancer (CRC) as an example, I review how heterotypic cells differentially communicate to support emergent malignancy. Studying tumors as integrated heterocellular systems - rather than as solitary expansions of mutated cells - may reveal novel ways to treat cancer.
组织包含多种不同的细胞类型，可被视为异细胞系统。不同细胞之间的信号传导使组织能够实现单一细胞类型无法单独达成的表型。这种新出现的组织水平表型可以说是“依赖于”异细胞信号传导。本文提出癌症也是一种依赖于异细胞信号传导的新出现表型。以结直肠癌（CRC）为例，我回顾了异型细胞如何进行差异通讯以支持新出现的恶性肿瘤。将肿瘤作为整合的异细胞系统来研究——而不是作为突变细胞的单独增殖——可能会揭示治疗癌症的新方法。
