Noorani Imran
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK
Philos Trans R Soc Lond B Biol Sci. 2017 Apr 19;372(1718). doi: 10.1098/rstb.2016.0191.
For precise motor control, we must be able to not only initiate movements with appropriate timing, but also stop them. The importance of stopping tended to be overlooked in research in favour of studying movement itself, so we are still only beginning to understand the neural basis of action cancellation. However, the development of models of behaviour in a wider range of tasks, and their relation to neural recordings has provided great insight into the underlying neurophysiology. Here we focus on developments of the linear approach to threshold with ergodic rate (LATER) model, relating these to complementary neurophysiological studies. It is tempting to consider that there may be a unifying mechanism for cancelling impending decisions in many contexts and how future efforts may clarify this possibility.This article is part of the themed issue 'Movement suppression: brain mechanisms for stopping and stillness'.
为了实现精确的运动控制,我们不仅必须能够在适当的时间发起动作,还必须能够停止动作。在研究中,停止动作的重要性往往被忽视,研究重点倾向于运动本身,因此我们对动作取消的神经基础仍只是刚刚开始了解。然而,在更广泛的任务中行为模型的发展及其与神经记录的关系,为潜在的神经生理学提供了深刻见解。在这里,我们重点关注具有遍历率的线性阈值方法(LATER)模型的发展,并将其与互补的神经生理学研究联系起来。人们不禁会想,在许多情况下,可能存在一种统一的机制来取消即将做出的决策,以及未来的研究如何能够阐明这种可能性。本文是主题为“运动抑制:停止和静止的脑机制”特刊的一部分。