Paul Sudip, Ali Md Yousuf, Rumpa Nur-E-Noushin, Tanvir E M, Hossen Md Sakib, Saha Moumoni, Bhoumik Nikhil Chandra, Gan Siew Hua, Khalil Md Ibrahim
Laboratory of Preventive and Integrative Biomedicine, Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
Laboratory of Preventive and Integrative Biomedicine, Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh; Veterinary Drug Residue Analysis Division, Institute of Food & Radiation Biology, Atomic Energy Research Establishment, Savar, Dhaka 1349, Bangladesh.
Evid Based Complement Alternat Med. 2017;2017:4686104. doi: 10.1155/2017/4686104. Epub 2017 Jan 22.
This study was undertaken to investigate the toxicological profile of a methanolic extract of fruit in rats by conducting hematological, biochemical, and histopathological examinations. Long Evans rats were divided into four groups, each with 6 animals, and were treated with three oral doses (250, 500, and 1000 mg/kg) once daily for 21 days. The extract did not cause significant changes in body and relative organ weight, percent water content, or hematological parameters at any administered doses. However, a significant dose-dependent positive effect in serum lipid profile and all atherogenic indices including the cardiac risk ratio, Castelli's risk index-2, and the atherogenic coefficient were observed. Significant increases in the levels of iron and decreases in serum alkaline phosphatase, alanine transaminase, and lactate dehydrogenase activities and the levels of serum glucose were noted when the extract was administered at the highest dose (1000 mg/kg). Histopathological examination of the target tissues further confirmed that the extract was safe and had no observed toxicological features. Our study indicates that fruit is nontoxic, has the potential to be effective against atherosclerosis, and may be used as a hepatoprotectant. The fruit extract is also beneficial to those with iron deficiency and hyperglycemia.
本研究旨在通过进行血液学、生物化学和组织病理学检查，调查水果甲醇提取物对大鼠的毒理学特征。将长 Evans 大鼠分为四组，每组 6 只动物，每天口服三种剂量（250、500 和 1000 mg/kg），持续 21 天。在任何给药剂量下，提取物均未引起体重、相对器官重量、水分含量百分比或血液学参数的显著变化。然而，观察到血清脂质谱和所有动脉粥样硬化指数（包括心脏风险比、卡斯泰利风险指数 -2 和动脉粥样硬化系数）存在显著的剂量依赖性积极影响。当以最高剂量（1000 mg/kg）给药提取物时，铁水平显著升高，血清碱性磷酸酶、丙氨酸转氨酶和乳酸脱氢酶活性以及血清葡萄糖水平显著降低。对目标组织的组织病理学检查进一步证实该提取物是安全的，未观察到毒理学特征。我们的研究表明，该水果无毒，具有抗动脉粥样硬化的潜力，可作为肝保护剂。水果提取物对缺铁和高血糖患者也有益。
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