Soliman Hany A G, Mac-Thiong Jean-Marc, Levasseur Annie, Parent Stefan, Petit Yvan
Department of Surgery, University of Montreal, Montreal, QC, Canada.; Research Center, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.; Research Center, CHU Sainte-Justine, Montreal, QC, Canada.; Al Zahraa Univeristy Hospital, Al Azhar University, Cairo, Egypt.
Department of Surgery, University of Montreal, Montreal, QC, Canada.; Research Center, Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.; Research Center, CHU Sainte-Justine, Montreal, QC, Canada.
Asian Spine J. 2017 Feb;11(1):57-62. doi: 10.4184/asj.2017.11.1.57. Epub 2017 Feb 17.
Cohort study.
The aim of this study is to propose and evaluate a new technique to assess bone mineral density of fractured vertebrae using quantitative computed tomography (QCT).
There is no available technique to estimate bone mineral density (BMD) at the fractured vertebra because of the alterations in bony structures at the fracture site.
Forty patients with isolated fracture from T10 to L2 were analyzed from the vertebrae above and below the fracture level. Apparent density (AD) was measured based on the relationship between QCT images attenuation coefficients and the density of calibration objects. AD of 8 independent regions of interest (ROI) within the vertebral body and 2 ROI within the pedicles of vertebrae above and below the fractured vertebra were measured. At the level of the fractured vertebra, AD was measured at the pedicles, which are typically intact. AD of the fractured vertebral body was linearly interpolated, based on the assumption that AD at the fractured vertebra is equivalent to the average AD measured in vertebrae adjacent to the fracture. Estimated and measured AD of the pedicles at the fractured level were compared to verify our assumption of linear interpolation from adjacent vertebrae.
The difference between the measured and the interpolated density of the pedicles at the fractured vertebra was 0.006 and 0.003 g/cm for right and left pedicle respectively. The highest mean AD located at the pedicles and the lowest mean AD was found at the anterior ROI of the vertebral body. Significant negative correlation exist between age and AD of ROI in the vertebral body.
This study suggests that the proposed technique is adequate to estimate the AD of a fractured vertebra from the density of adjacent vertebrae.
队列研究。
本研究旨在提出并评估一种使用定量计算机断层扫描（QCT）评估骨折椎体骨密度的新技术。
由于骨折部位骨结构的改变，目前尚无可用技术来估计骨折椎体的骨密度（BMD）。
对40例T10至L2单发性骨折患者骨折水平上下的椎体进行分析。基于QCT图像衰减系数与校准物体密度之间的关系测量表观密度（AD）。测量骨折椎体上下椎体椎体内8个独立感兴趣区域（ROI）以及椎弓根内2个ROI的AD。在骨折椎体水平，在通常完整的椎弓根处测量AD。基于骨折椎体的AD等同于骨折相邻椎体测量的平均AD这一假设，对骨折椎体的AD进行线性插值。比较骨折水平椎弓根的估计AD和测量AD，以验证我们从相邻椎体进行线性插值的假设。
骨折椎体椎弓根测量密度与插值密度之间的差异，右侧椎弓根为0.006 g/cm，左侧椎弓根为0.003 g/cm。平均AD最高位于椎弓根，最低位于椎体前部ROI。椎体ROI的年龄与AD之间存在显著负相关。
本研究表明，所提出的技术足以根据相邻椎体的密度估计骨折椎体的AD。
