变形链球菌OMZ175血清型f多糖抗原的结构研究。
Structural studies of the serotype-f polysaccharide antigen from Streptococcus mutans OMZ175.
作者信息
Linzer R, Reddy M S, Levine M J
机构信息
Department of Endodontics, State University of New York at Buffalo 14214.
出版信息
Infect Immun. 1987 Dec;55(12):3006-10. doi: 10.1128/iai.55.12.3006-3010.1987.
Abstract
The serotype f antigen of Streptococcus mutans has been described as a rhamnose-glucose polysaccharide associated with the bacterial cell wall. In this study, the structure of serotype f polysaccharide was examined by analyses of the methylated derivatives of the antigen and the periodate-oxidized antigen. Methylated derivatives were characterized with a gas chromatograph-mass spectrometer. The polysaccharide appeared to have a backbone of alternating 1,3- and 1,2,3-linked rhamnose units. Branching occurred at the 3-position of the 1,2,3-linked rhamnose. Side chains were composed of terminal alpha-linked glucose units. A small proportion of longer side chains containing 1,2- and 1,6-linked glucose units were noted in some preparations; however, these determinants were not reactive with serotype f antisera.
摘要
变形链球菌的血清型f抗原被描述为一种与细菌细胞壁相关的鼠李糖-葡萄糖多糖。在本研究中，通过对抗原的甲基化衍生物和高碘酸盐氧化抗原进行分析，研究了血清型f多糖的结构。甲基化衍生物用气相色谱-质谱仪进行表征。该多糖似乎具有由交替的1,3-和1,2,3-连接的鼠李糖单元组成的主链。分支发生在1,2,3-连接的鼠李糖的3位。侧链由末端α-连接的葡萄糖单元组成。在一些制剂中发现了一小部分含有1,2-和1,6-连接的葡萄糖单元的较长侧链；然而，这些决定簇与血清型f抗血清无反应性。
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