Department of General Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Department of Intensive Care Unit, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
J Cell Mol Med. 2017 Sep;21(9):1687-1697. doi: 10.1111/jcmm.13112. Epub 2017 Feb 28.
Sepsis remains a leading cause of death worldwide, despite advances in critical care, and understanding of the pathophysiology and treatment strategies. No specific therapy or drugs are available for sepsis. Neutrophils play a critical role in controlling infection under normal conditions, and it is suggested that their migration and antimicrobial activity are impaired during sepsis which contribute to the dysregulation of immune responses. Recent studies further demonstrated that interruption or reversal of the impaired migration and antimicrobial function of neutrophils improves the outcome of sepsis in animal models. In this review, we provide an overview of the associated mediators and signal pathways involved which govern the survival, migration and antimicrobial function of neutrophils in sepsis, and discuss the potential of neutrophils as a target to specifically diagnose and/or predict the outcome of sepsis.
尽管在重症监护和对发病机制及治疗策略的理解方面取得了进展，但脓毒症仍然是全球主要的死亡原因。目前尚无针对脓毒症的特定疗法或药物。在正常情况下，中性粒细胞在控制感染方面发挥着关键作用，有人提出，在脓毒症期间，其迁移和抗菌活性受损，这导致免疫反应失调。最近的研究进一步表明，中断或逆转受损的中性粒细胞迁移和抗菌功能可改善动物模型中脓毒症的结局。在这篇综述中，我们概述了与脓毒症中中性粒细胞的存活、迁移和抗菌功能相关的介质和信号通路，讨论了将中性粒细胞作为特定诊断和/或预测脓毒症结局的靶点的潜力。
