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揭示长链非编码RNA在癌症干细胞中的作用。

Uncovering the roles of long non-coding RNAs in cancer stem cells.

作者信息

Huang Xiaoxing, Xiao Ruijing, Pan Shan, Yang Xiangyong, Yuan Wen, Tu Zhenbo, Xu Ming, Zhu Yufan, Yin Qian, Wu Yingjie, Hu Weidong, Shao Liang, Xiong Jie, Zhang Qiuping

机构信息

Department of Immunology, School of Basic Medical Science, Wuhan University, Wuhan, 430071, China.

Hubei University of Technology Engineering and Technology College, Wuhan, 430000, China.

出版信息

J Hematol Oncol. 2017 Feb 28;10(1):62. doi: 10.1186/s13045-017-0428-9.

DOI:10.1186/s13045-017-0428-9
PMID:28245841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5331729/
Abstract

Cancer has been a major public health problem that has threatened human life worldwide throughout history. The main causes that contribute to the poor prognosis of cancer are metastasis and recurrence. Cancer stem cells are a group of tumor cells that possess self-renewal and differentiation ability, which is a vital cause of cancer metastasis and recurrence. Long non-coding RNAs refer to a class of RNAs that are longer than 200 nt and have no potential to code proteins, some of which can be specifically expressed in different tissues and different tumors. Long non-coding RNAs have great biological significance in the occurrence and progression of cancers. However, how long non-coding RNAs interact with cancer stem cells and then affect cancer metastasis and recurrence is not yet clear. Therefore, this review aims to summarize recent studies that focus on how long non-coding RNAs impact tumor occurrence and progression by affecting cancer stem cell self-renewal and differentiation in liver cancer, prostate cancer, breast cancer, and glioma.

摘要

癌症一直是一个重大的公共卫生问题，有史以来在全球范围内威胁着人类生命。导致癌症预后不良的主要原因是转移和复发。癌症干细胞是一群具有自我更新和分化能力的肿瘤细胞，这是癌症转移和复发的一个重要原因。长链非编码RNA是一类长度超过200个核苷酸且无编码蛋白质潜力的RNA，其中一些可以在不同组织和不同肿瘤中特异性表达。长链非编码RNA在癌症的发生和发展中具有重要的生物学意义。然而，长链非编码RNA如何与癌症干细胞相互作用，进而影响癌症转移和复发尚不清楚。因此，本综述旨在总结近期的研究，这些研究聚焦于长链非编码RNA如何通过影响肝癌、前列腺癌、乳腺癌和神经胶质瘤中癌症干细胞的自我更新和分化来影响肿瘤的发生和发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe5c/5331729/950aa5b2679b/13045_2017_428_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe5c/5331729/55516d20bcdf/13045_2017_428_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe5c/5331729/f6afc1851f16/13045_2017_428_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe5c/5331729/180054b51a3d/13045_2017_428_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe5c/5331729/e8a980efa336/13045_2017_428_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe5c/5331729/950aa5b2679b/13045_2017_428_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe5c/5331729/55516d20bcdf/13045_2017_428_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe5c/5331729/f6afc1851f16/13045_2017_428_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe5c/5331729/180054b51a3d/13045_2017_428_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe5c/5331729/e8a980efa336/13045_2017_428_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe5c/5331729/950aa5b2679b/13045_2017_428_Fig5_HTML.jpg

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Cancer Lett. 2017 Apr 10;391:100-113. doi: 10.1016/j.canlet.2017.01.026. Epub 2017 Jan 25.
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Identifying and targeting cancer stem cells in the treatment of gastric cancer.
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Cancer Cell Int. 2024 Jul 28;24(1):269. doi: 10.1186/s12935-024-03408-z.
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Integrinβ-1 in disorders and cancers: molecular mechanisms and therapeutic targets.整合素β-1在疾病与癌症中的作用：分子机制与治疗靶点
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