Tedesco Francesco Saverio, Moyle Louise A, Perdiguero Eusebio
Department of Cell and Developmental Biology, University College London, Gower Street, WC1E 6DE, London, UK.
Cell Biology Group, Department of Experimental and Health Sciences (DCEXS), Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), 08003, Barcelona, Spain.
Methods Mol Biol. 2017;1556:129-147. doi: 10.1007/978-1-4939-6771-1_7.
Skeletal muscle regeneration is mainly enabled by a population of adult stem cells known as satellite cells. Satellite cells have been shown to be indispensable for adult skeletal muscle repair and regeneration. In the last two decades, other stem/progenitor cell populations resident in the skeletal muscle interstitium have been identified as "collaborators" of satellite cells during regeneration. They also appear to have a key role in replacing skeletal muscle with adipose, fibrous, or bone tissue in pathological conditions. Here, we review the role and known functions of these different interstitial skeletal muscle cell types and discuss their role in skeletal muscle tissue homeostasis, regeneration, and disease, including their therapeutic potential for cell transplantation protocols.
骨骼肌再生主要由一群称为卫星细胞的成体干细胞实现。卫星细胞已被证明对成年骨骼肌的修复和再生不可或缺。在过去二十年中，驻留在骨骼肌间质中的其他干细胞/祖细胞群体已被确定为再生过程中卫星细胞的“合作者”。它们在病理状态下用脂肪、纤维或骨组织替代骨骼肌方面似乎也起着关键作用。在这里，我们综述了这些不同的间质骨骼肌细胞类型的作用和已知功能，并讨论它们在骨骼肌组织稳态、再生和疾病中的作用，包括它们在细胞移植方案中的治疗潜力。
