健康与疾病状态下的人类调节性B细胞：治疗潜力
Human regulatory B cells in health and disease: therapeutic potential.
作者信息
Mauri Claudia, Menon Madhvi
出版信息
J Clin Invest. 2017 Mar 1;127(3):772-779. doi: 10.1172/JCI85113.
Abstract
Regulatory B cells (Bregs) modulate immune responses predominantly, although not exclusively, via the release of IL-10. The importance of human Bregs in the maintenance of immune homeostasis comes from a variety of immune-related pathologies, such as autoimmune diseases, cancers, and chronic infections that are often associated with abnormalities in Breg numbers or function. A continuous effort toward understanding Breg biology in healthy individuals will provide new opportunities to develop Breg immunotherapy that could prove beneficial in treating various immune-mediated pathologies. In this Review, we discuss findings regarding human Bregs, including their mechanisms of suppression and role in different disease settings. We also propose several therapeutic strategies targeting Bregs for better management of immune disorders.
摘要
调节性B细胞（Bregs）主要通过释放白细胞介素-10来调节免疫反应，不过并非唯一途径。人类Bregs在维持免疫稳态中的重要性源于多种与免疫相关的病理状况，如自身免疫性疾病、癌症以及慢性感染，这些病症常常与Bregs数量或功能异常相关。持续致力于了解健康个体中的Breg生物学特性，将为开发Breg免疫疗法提供新机遇，这种疗法可能对治疗各种免疫介导的病理状况有益。在本综述中，我们讨论了有关人类Bregs的研究结果，包括其抑制机制以及在不同疾病背景下的作用。我们还提出了几种针对Bregs的治疗策略，以更好地管理免疫紊乱。
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