Fim-3区域频繁参与弗氏小鼠白血病病毒诱导的小鼠骨髓性白血病。
Frequent involvement of the fim-3 region in Friend murine leukemia virus-induced mouse myeloblastic leukemias.
作者信息
Bordereaux D, Fichelson S, Sola B, Tambourin P E, Gisselbrecht S
机构信息
Laboratoire Immunologie et Virologie des Tumeurs, Institut National de la Santé et de la Recherche Médicale, Paris, France.
出版信息
J Virol. 1987 Dec;61(12):4043-5. doi: 10.1128/JVI.61.12.4043-4045.1987.
Abstract
fim-3 is a new proviral integration region involved in 23% (16 of 68) of Friend murine leukemia virus-induced myeloblastic leukemias. This region is distinct from 20 oncogenes and from putative oncogenes tested so far. Proviruses are integrated in a 16-kilobase region, always in the same orientation. No RNA expression of fim-3 was detected.
摘要
fim-3是一个新的前病毒整合区域，在23%（68例中的16例）的弗氏鼠白血病病毒诱导的成髓细胞白血病中出现。该区域不同于目前已检测的20种癌基因和假定癌基因。前病毒整合在一个16千碱基的区域，且总是以相同方向整合。未检测到fim-3的RNA表达。
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