Zofkova I, Davis M, Blahos J
Institute of Endocrinology, Prague, Czech Republic.
Physiol Res. 2017 Jul 18;66(3):391-402. doi: 10.33549/physiolres.933454. Epub 2017 Feb 28.
The protective role of nutrition factors such as calcium, vitamin D and vitamin K for the integrity of the skeleton is well understood. In addition, integrity of the skeleton is positively influenced by certain trace elements (e.g. zinc, copper, manganese, magnesium, iron, selenium, boron and fluoride) and negatively by others (lead, cadmium, cobalt). Deficiency or excess of these elements influence bone mass and bone quality in adulthood as well as in childhood and adolescence. However, some protective elements may become toxic under certain conditions, depending on dosage (serum concentration), duration of treatment and interactions among individual elements. We review the beneficial and toxic effects of key elements on bone homeostasis.
钙、维生素D和维生素K等营养因素对骨骼完整性的保护作用已得到充分理解。此外，某些微量元素（如锌、铜、锰、镁、铁、硒、硼和氟化物）对骨骼完整性有积极影响，而其他一些元素（铅、镉、钴）则有消极影响。这些元素的缺乏或过量会影响成年期以及儿童和青少年时期的骨量和骨质。然而，某些保护性元素在特定条件下可能会变得有毒，这取决于剂量（血清浓度）、治疗持续时间以及各元素之间的相互作用。我们综述了关键元素对骨稳态的有益和毒性作用。
