Djilali S, Parodi A L, Levy D, Cockerell G L
Laboratoire d'Anatomie Pathologique et Immunogénétique-INRA Ecole Nationale Vétérinaire, Alfort, France.
Leukemia. 1987 Nov;1(11):777-81.
The hematological and neoplastic disorders induced in sheep by experimental bovine leukemia virus (BLV) infection are described. Seventeen of 19 BLV-inoculated sheep developed a marked increase in peripheral blood lymphocytes by 36 months after the intraperitoneal injection of peripheral blood lymphocytes from a BLV-infected cow. This increase correlated with an increase in the number of circulating B lymphocytes as demonstrated by the presence of surface immunoglobulins (SIg) and a high cell proliferative response to lipopolysaccharide and was considered to be a persistent B cell lymphocytosis. Lymphosarcoma developed in five BLV-infected sheep between 19 and 38 months postinoculation and was preceded in four out of five of these cases by an elevation in peripheral blood lymphocytes which began 4 to 26 months before death due to lymphosarcoma. The majority of tumor cells in all lymphosarcoma cases were of the centroblastic type, and in two cases in which the presence of SIg was assayed, the majority of tumor cells were SIg-positive. Thus, BLV-induced lymphosarcoma in sheep seems to be a B lymphocyte-derived tumor.
本文描述了实验性牛白血病病毒（BLV）感染诱导绵羊发生的血液学和肿瘤性疾病。在19只接种BLV的绵羊中，有17只在腹腔注射来自BLV感染牛的外周血淋巴细胞后36个月，外周血淋巴细胞显著增多。这种增多与循环B淋巴细胞数量的增加相关，表面免疫球蛋白（SIg）的存在以及对脂多糖的高细胞增殖反应证明了这一点，这被认为是一种持续性B细胞淋巴细胞增多症。5只BLV感染的绵羊在接种后19至38个月发生了淋巴肉瘤，其中5例中有4例在因淋巴肉瘤死亡前4至26个月外周血淋巴细胞升高。所有淋巴肉瘤病例中的大多数肿瘤细胞为中心母细胞型，在2例检测了SIg的病例中，大多数肿瘤细胞SIg呈阳性。因此，绵羊中BLV诱导的淋巴肉瘤似乎是一种B淋巴细胞源性肿瘤。
