Manzari V, Gismondi A, Barillari G, Morrone S, Modesti A, Albonici L, De Marchis L, Fazio V, Gradilone A, Zani M
Dipartimento di Medicina Sperimentale e Scienze Biochimiche II, Università di Roma, Tor Vergata, Italy.
Science. 1987 Dec 11;238(4833):1581-3. doi: 10.1126/science.2825353.
A new human retrovirus was isolated from a continuous cell line derived from a patient with CD4+ Tac- cutaneous T cell lymphoma/leukemia. This virus is related to but distinct from human T cell leukemia/lymphoma virus types I and II (HTLV-I and HTLV-II) and human immunodeficiency virus (HIV-1). With the use of a fragment of provirus cloned from one patient with T cell leukemia, closely related sequences were found in DNA of the cell line and of tumor cells from seven other patients with the same disease; these sequences were only distantly related to HTLV-I. The phenotype of the cells and the clinical course of the disease were clearly distinguishable from leukemia associated with HTLV-I. All patients and the wife of one patient showed a weak serological cross-reactivity with both HTLV-I and HIV-1 antigens. None of the patients proved to be at any apparent risk for HIV-1 infection. The name proposed for this virus is HTLV-V, and the date indicate that it may be a primary etiological factor in the major group of cutaneous T cell lymphomas/leukemias, including the sporadic lymphomas known as mycoses fungoides.
从一名患有CD4 + Tac皮肤T细胞淋巴瘤/白血病患者的连续细胞系中分离出一种新的人类逆转录病毒。该病毒与人类T细胞白血病/淋巴瘤病毒I型和II型（HTLV-I和HTLV-II）以及人类免疫缺陷病毒（HIV-1）相关，但又有所不同。利用从一名T细胞白血病患者克隆的前病毒片段，在该细胞系以及其他7名患有相同疾病患者的肿瘤细胞DNA中发现了密切相关的序列；这些序列与HTLV-I仅有远缘关系。细胞的表型和疾病的临床进程与HTLV-I相关的白血病明显不同。所有患者以及一名患者的妻子与HTLV-I和HIV-1抗原均表现出微弱的血清学交叉反应。没有一名患者被证明有感染HIV-1的明显风险。提议将这种病毒命名为HTLV-V，数据表明它可能是包括称为蕈样肉芽肿的散发性淋巴瘤在内的主要皮肤T细胞淋巴瘤/白血病组中的主要病因。
