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Biology and pharmacology of recombinant human interleukin-1 beta-induced rat ear inflammation.

作者信息

De Young L M, Spires D A, Kheifets J, Terrell T G

机构信息

Syntex Research, Palo Alto, CA 94304.

出版信息

Agents Actions. 1987 Aug;21(3-4):325-7. doi: 10.1007/BF01966505.

DOI:10.1007/BF01966505
PMID:2825480
Abstract

A single, 10 ng intradermal injection of human recombinant interleukin-1 beta (rIL-1 beta) into rat ears produced acute inflammation. Tissue wet weight (edema) and total myeloperoxidase activity (PMN accumulation), peaked at 3 hours and returned to base line at 3 days. Given orally, 1 hour prior to rIL-1 beta injection, cyproheptadine, dexamethasone, conventional NSAID's, or mixed cyclooxygenase/lipoxygenase inhibitors were potent antagonists of edema and moderate antagonists of PMN accumulation. In addition, the putative DMARD's, auranofin, dapsone, and levamisole were effective inhibitors of rIL-1 beta induced inflammation.

摘要

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引用本文的文献

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本文引用的文献

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Sulfonamides and sulfones in dermatologic therapy.皮肤科治疗中的磺胺类药物和砜类药物。
Int J Dermatol. 1981 Mar;20(2):81-8. doi: 10.1111/j.1365-4362.1981.tb00406.x.
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Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker.皮肤炎症的测量：用酶标记物评估中性粒细胞含量。
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The role of arachidonic acid metabolism in the activities of interleukin 1 and 2.花生四烯酸代谢在白细胞介素1和2活性中的作用。
内毒素刺激巨噬细胞产生肿瘤坏死因子的药理学调节：金诺芬及其他金制剂化合物的体外和体内作用
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Recombinant interleukin-1 and tumor necrosis factor induce neutrophil migration "in vivo" by indirect mechanisms.重组白细胞介素-1和肿瘤坏死因子通过间接机制诱导中性粒细胞“在体内”迁移。
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Passive immunization against tumour necrosis factor-alpha (TNF-alpha) and IL-1 beta protects from LPS enhancing glomerular injury in nephrotoxic nephritis in rats.被动免疫抗肿瘤坏死因子-α（TNF-α）和白细胞介素-1β可保护大鼠免受脂多糖（LPS）加重肾毒性肾炎中肾小球损伤的影响。
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In vivo inflammatory activity of epidermal cell-derived thymocyte activating factor and recombinant interleukin 1 in the mouse.表皮细胞衍生的胸腺细胞激活因子及重组白细胞介素1在小鼠体内的炎性活性
J Clin Invest. 1986 Mar;77(3):1020-7. doi: 10.1172/JCI112354.
5
Normal epidermis contains high amounts of natural tissue IL 1 biochemical analysis by HPLC identifies a MW approximately 17 Kd form with a P1 5.7 and a MW approximately 30 Kd form.正常表皮含有大量天然组织白细胞介素1。通过高效液相色谱法进行的生化分析鉴定出一种分子量约为17千道尔顿、pI为5.7的形式以及一种分子量约为30千道尔顿的形式。
Lymphokine Res. 1986 Spring;5(2):105-18.
6
Modulation of the release of histamine and arachidonic acid metabolites from human basophils and mast cells by auranofin.金诺芬对人嗜碱性粒细胞和肥大细胞中组胺及花生四烯酸代谢产物释放的调节作用
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Cultured human vascular endothelial cells acquire adhesiveness for neutrophils after stimulation with interleukin 1, endotoxin, and tumor-promoting phorbol diesters.培养的人血管内皮细胞在受到白细胞介素1、内毒素和促肿瘤佛波酯刺激后，会获得对中性粒细胞的黏附性。
J Immunol. 1986 Jan;136(2):649-54.