Guilloto Caballero S, García Madrona J L, Colmenero Reina E
Departamento de Córnea y Cirugía Refractiva, Clínica Vistalaser Oftalmología, Málaga, España.
Departamento de Córnea y Cirugía Refractiva, Clínica Vistalaser Oftalmología, Málaga, España.
Arch Soc Esp Oftalmol. 2017 Nov;92(11):509-515. doi: 10.1016/j.oftal.2016.12.018. Epub 2017 Feb 28.
The objective of this study was to determine the clinical benefits of pulsed light therapy for the treatment of Dry Eye Syndrome (DES) due to the decrease in aqueous tear production (aqueous deficient DES) and/or excessive tear evaporation (evaporative DES) due to Meibomian Gland Dysfunction (MGD).
A study was conducted on 72 eyes corresponding to 36 patients with DES. Out of these 72 eyes, 60 underwent refractive surgery (48 with femtosecond laser, 6 were operated with a mechanical microkeratome, and 6 with refractive photo-keratectomy[RPK], 6 treated with phacoemulsification, and 6 with no previous surgical treatment. Pulsed laser light (Intense Pulsed Light Regulated [IRPL]) was use to stimulate the secretion of the Meibomian glands during 4 sessions, one every 15 days.
Patients with aqueous deficient DES did not show any improvement. Eyes with no previous surgery and those treated with phacoemulsification and PRK had a favourable outcome. On the other hand, less conclusive results were observed in the eyes treated with excimer laser.
This treatment could be very helpful to treat evaporative DES produced by MGD. On the other hand, it is not helpful for those cases related to an isolated damage in the aqueous phase, or the mucin phase.
本研究的目的是确定脉冲光疗法对治疗因泪液分泌减少（水液缺乏型干眼综合征）和/或因睑板腺功能障碍（MGD）导致的泪液过度蒸发（蒸发型干眼综合征）所引起的干眼综合征（DES）的临床益处。
对36例干眼综合征患者的72只眼睛进行了一项研究。在这72只眼睛中，60只接受了屈光手术（48只使用飞秒激光，6只使用机械微型角膜刀，6只使用屈光性光角膜切除术[RPK]，6只接受了超声乳化治疗，6只未接受过手术治疗。使用脉冲激光（强脉冲光调节[IRPL]）在4个疗程中刺激睑板腺分泌，每15天进行一次。
水液缺乏型干眼综合征患者未显示出任何改善。未接受过手术的眼睛以及接受超声乳化和PRK治疗的眼睛取得了良好的效果。另一方面，准分子激光治疗的眼睛观察到的结果不太明确。
这种治疗方法可能对治疗MGD引起的蒸发型干眼综合征非常有帮助。另一方面，对于与水相或粘蛋白相单独受损相关的病例没有帮助。
