过敏性疾病中的微生物群：当前认识与未来机遇——美国过敏、哮喘与免疫学会和欧洲变态反应与临床免疫学会2017年PRACTALL文件
The microbiome in allergic disease: Current understanding and future opportunities-2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology.
作者信息
Huang Yvonne J, Marsland Benjamin J, Bunyavanich Supinda, O'Mahony Liam, Leung Donald Y M, Muraro Antonella, Fleisher Thomas A
机构信息
Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Michigan, Ann Arbor, Mich.
Service de Pneumologie, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
出版信息
J Allergy Clin Immunol. 2017 Apr;139(4):1099-1110. doi: 10.1016/j.jaci.2017.02.007. Epub 2017 Feb 28.
Abstract
PRACTALL is a joint initiative of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology to provide shared evidence-based recommendations on cutting-edge topics in the field of allergy and immunology. PRACTALL 2017 is focused on what has been established regarding the role of the microbiome in patients with asthma, atopic dermatitis, and food allergy. This is complemented by outlining important knowledge gaps regarding its role in allergic disease and delineating strategies necessary to fill these gaps. In addition, a review of progress in approaches used to manipulate the microbiome will be addressed, identifying what has and has not worked to serve as a baseline for future directions to intervene in allergic disease development, progression, or both.
摘要
PRACTALL是美国过敏、哮喘与免疫学会和欧洲过敏与临床免疫学会的一项联合倡议，旨在就过敏和免疫学领域的前沿话题提供基于证据的共同建议。PRACTALL 2017聚焦于微生物群在哮喘、特应性皮炎和食物过敏患者中的作用已明确的方面。通过概述其在过敏性疾病中的作用方面的重要知识空白，并勾勒填补这些空白所需的策略，对此进行补充。此外，还将对用于操控微生物群的方法的进展进行综述，确定哪些方法有效以及哪些方法无效，以此作为未来干预过敏性疾病发生、发展或两者的方向的基线。
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