Department of Physiology, K.S. Hegde Medical Academy, Nitte University, Mangalore, India.
Department of Physiology, K.S. Hegde Medical Academy, Nitte University, Mangalore, India.
J Natl Med Assoc. 2017;109(1):9-13. doi: 10.1016/j.jnma.2017.01.005. Epub 2017 Jan 31.
Advanced age is associated with an accumulation of free radical damage, which leads to physiological and clinical modifications. Numerous pharmaceutical and nutraceuticals are considered to influence longevity and prompting healthy ageing. Therefore, the current study attempted to investigate Curcumin's role in the inflammatory indices as anti-ageing marker in albino Wistar rats.
Twelve months old rats were used in the study, grouped as Normal control (NC), Sham control (SC), Curcumin-1, Curcumin-2 and Curcumin-3. Last three groups received Curcumin at the dosages of 100 mg, 200 mg and 400 mg/kg body weight respectively. After six months of intervention, blood was collected for the estimation of C-reactive protein (CRP), Serum Albumin, Globulin, Lymphocyte percentage, Total Antioxidant Capacity (TAC), Malondialdehyde (MDA), Superoxide Dismutase (SOD) and Nitric Oxide (NO) level using standard procedures.
There was a significant decline in the CRP level (p < 0.05) in rats treated with 200 mg and 400 mg of Curcumin/kg body weight. The MDA level was found to be significantly increased (p < 0.05) in animals fed with 400 mg of Curcumin/kg body weight as compared to NC. The NO level was increased significantly (p < 0.05) in rats treated with 200 and 400 mg of Curcumin/kg body weight.
Finding of the study suggests that Curcumin exhibits favorable influence in slowing down of ageing process by suppressing age-related changes in inflammatory indices.
衰老与自由基损伤的积累有关，这导致了生理和临床的改变。许多药物和营养保健品被认为可以影响寿命并促进健康衰老。因此，本研究试图探讨姜黄素在炎症指标中的作用，作为白化 Wistar 大鼠的抗衰老标志物。
本研究使用 12 个月大的大鼠，分为正常对照组（NC）、假手术对照组（SC）、姜黄素-1 组、姜黄素-2 组和姜黄素-3 组。后三组分别给予 100mg、200mg 和 400mg/kg 体重的姜黄素。干预 6 个月后，采集血液，用标准方法测定 C 反应蛋白（CRP）、血清白蛋白、球蛋白、淋巴细胞百分比、总抗氧化能力（TAC）、丙二醛（MDA）、超氧化物歧化酶（SOD）和一氧化氮（NO）水平。
200mg 和 400mg/kg 体重的姜黄素处理组大鼠的 CRP 水平显著下降（p<0.05）。与 NC 相比，400mg/kg 体重的姜黄素喂养组大鼠的 MDA 水平显著升高（p<0.05）。200mg 和 400mg/kg 体重的姜黄素处理组大鼠的 NO 水平显著升高（p<0.05）。
研究结果表明，姜黄素通过抑制与年龄相关的炎症指标变化，对减缓衰老过程具有有利影响。
