Ragona G, Sirianni M C
Department of Experimental Medicine, University of Rome, La Sapienza, Italy.
Cancer Detect Prev Suppl. 1987;1:549-52.
Patients affected by AIDS related-complex (ARC) showed several immunological abnormalities that could lead to a disregulation of immunosurveillance against viral latent infections. We report Epstein-Barr virus (EBV) reactivation was found in seven of eight ARC patients and in two of seven affected by persistent generalized lymphoadenopathy. These patients showed either elevated levels of circulating EBV-positive transformed cells and/or depressed EBV-specific T cell cytotoxicity as assessed by the regression assay. Natural killer cell activity was found to be decreased and correlated with evidence of circulating EBV-infected cells and with impaired EBV-specific immune control. Our data demonstrate that loss of control of EBV latency in the infected host by specific immune mechanisms increases the risk for EBV reactivation and emergence of clones with unlimited growth potential. A role of EBV as a cofactor in the development of ARC is suggested.
患有艾滋病相关综合征（ARC）的患者表现出多种免疫异常，这些异常可能导致针对病毒潜伏感染的免疫监视失调。我们报告，在8例ARC患者中有7例以及在7例持续性全身性淋巴结病患者中有2例发现了EB病毒（EBV）激活。通过回归分析评估，这些患者表现出循环中EBV阳性转化细胞水平升高和/或EBV特异性T细胞细胞毒性降低。发现自然杀伤细胞活性降低，且与循环中EBV感染细胞的证据以及EBV特异性免疫控制受损相关。我们的数据表明，特异性免疫机制对感染宿主中EBV潜伏的控制丧失会增加EBV激活以及具有无限生长潜力的克隆出现的风险。提示EBV在ARC发展中作为辅助因子发挥作用。
