Nagle J F
Department of Physics, Carnegie-Mellon University, Pittsburgh, Pennsylvania 15213.
J Bioenerg Biomembr. 1987 Oct;19(5):413-26. doi: 10.1007/BF00770027.
The large permeability of lipid bilayers to protons compared to other small ions calls for a special proton transport mechanism. At the present time, only mechanisms involving transient hydrogen-bonded chains of water can account for the experimental result that the conductance is nearly independent of pH. Three models involving transient hydrogen-bonded chains are discussed, including an outline of the kinetic calculations that lead to predictions of current versus voltage drop and current versus pH differences. These calculations can be compared to experiment to determine which, if any, of these models pertains to lipid bilayers.
与其他小离子相比，脂质双分子层对质子具有较大的通透性，这就需要一种特殊的质子转运机制。目前，只有涉及水的瞬态氢键链的机制才能解释电导率几乎与pH无关这一实验结果。讨论了三种涉及瞬态氢键链的模型，包括导致电流与电压降以及电流与pH差异预测的动力学计算概述。这些计算结果可以与实验进行比较，以确定这些模型中哪一个（如果有的话）适用于脂质双分子层。
