Han Xue, Wu Xia, Kelly Michael, Chen Xiongbiao
Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada.
Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada.
J Funct Biomater. 2017 Feb 28;8(1):8. doi: 10.3390/jfb8010008.
An aneurysm is a balloon-like bulge in the wall of blood vessels, occurring in major arteries of the heart and brain. Biodegradable polymeric stent-assisted coiling is expected to be the ideal treatment of wide-neck complex aneurysms. This paper presents the development of methods to fabricate and optimally design biodegradable polymeric stents for aneurysms treatment. Firstly, a dispensing-based rapid prototyping (DBRP) system was developed to fabricate coil and zigzag structures of biodegradable polymeric stents. Then, compression testing was carried out to characterize the radial deformation of the stents fabricated with the coil or zigzag structure. The results illustrated the stent with a zigzag structure has a stronger radial stiffness than the one with a coil structure. On this basis, the stent with a zigzag structure was chosen for the development of a finite element model for simulating the real compression tests. The result showed the finite element model of biodegradable polymeric stents is acceptable within a range of radial deformation around 20%. Furthermore, the optimization of the zigzag structure was performed with ANSYS DesignXplorer, and the results indicated that the total deformation could be decreased by 35.7% by optimizing the structure parameters, which would represent a significant advance of the radial stiffness of biodegradable polymeric stents.
动脉瘤是血管壁上的气球样膨出，发生于心脏和大脑的主要动脉。可生物降解聚合物支架辅助弹簧圈栓塞有望成为治疗宽颈复杂动脉瘤的理想方法。本文介绍了用于动脉瘤治疗的可生物降解聚合物支架的制造方法及优化设计的进展。首先，开发了一种基于点胶的快速成型（DBRP）系统来制造可生物降解聚合物支架的弹簧圈和之字形结构。然后，进行压缩测试以表征采用弹簧圈或之字形结构制造的支架的径向变形。结果表明，具有之字形结构的支架比具有弹簧圈结构的支架具有更强的径向刚度。在此基础上，选择了之字形结构的支架来建立有限元模型，以模拟实际压缩测试。结果表明，可生物降解聚合物支架的有限元模型在径向变形约20%的范围内是可接受的。此外，使用ANSYS DesignXplorer对之字形结构进行了优化，结果表明通过优化结构参数，总变形可降低35.7%，这将显著提高可生物降解聚合物支架的径向刚度。
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