Lin Xiaoti, Li Jingjing, Ying Mingang, Wei Fengqin, Xie Xiaoming
1Department of Breast Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China;2Department of Surgery, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, Fuzhou, China;3Department of Ophthalmology, Xiangyang Central Hospital, Teaching Hospital of Medical College of Hubei University of Arts and Science, Xiangyang, Hubei, China; and4Department of Emergency, Fujian Provincial 2nd People's Hospital, Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Am J Ther. 2017 Mar/Apr;24(2):e213-e221. doi: 10.1097/MJT.0000000000000410.
Colonic diverticular disease (CDD) and colonic diverticular hemorrhage (CDH) are the most common disorders in hospital admissions and outpatient health clinic visits. However, risk factors of CDD and CDH are complicated and need to be discussed. Diabetes mellitus (DM) has been related with CDD and CDH, but the associations remain ambiguous. Therefore, we performed a literature search for studies involving the associations among DM, morbidity of CDD, and incidence of CDH. Relative risks or odds ratios with their corresponding 95% confidence intervals (CIs) were combined and weighted to produce summary effect size. Sensitivity analysis and subgroup analysis were further performed. We selected 17 studies that involved a total of 8212 patients with diabetes, 381,579 controls without diabetes. We found that patients with DM had approximately 1.201 times higher CDD morbidity in prospective studies (95% CI, 1.135-1.270) with no significant heterogeneity (Q = 0.42, P = 0.519, I = 0%). DM was associated with a 52.8% increase in risk of CDH (95% CI, 14%-104%); we did not find significant heterogeneity among these studies (Q = 12.94, P = 0.114, I = 38.2%). This meta-analysis confirms that DM is an important risk factor for morbidities of CDD and CDH.
结肠憩室病（CDD）和结肠憩室出血（CDH）是住院患者和门诊就诊患者中最常见的疾病。然而，CDD和CDH的危险因素较为复杂，需要进行探讨。糖尿病（DM）与CDD和CDH有关，但这种关联仍不明确。因此，我们进行了一项文献检索，以查找涉及DM、CDD发病率和CDH发生率之间关联的研究。将相对风险或比值比及其相应的95%置信区间（CI）进行合并和加权，以得出汇总效应量。进一步进行了敏感性分析和亚组分析。我们选择了17项研究，共纳入8212例糖尿病患者和381579例非糖尿病对照。我们发现，在前瞻性研究中，糖尿病患者的CDD发病率大约高1.201倍（95%CI，1.135 - 1.270），且无显著异质性（Q = 0.42，P = 0.519，I² = 0%）。DM与CDH风险增加52.8%相关（95%CI，14% - 104%）；我们在这些研究中未发现显著异质性（Q = 12.94，P = 0.114，I² = 38.2%）。这项荟萃分析证实，DM是CDD和CDH发病的重要危险因素。
