用于生物组织中高速全场层析振动测量的多频扫描光学相干显微镜。
Multifrequency-swept optical coherence microscopy for highspeed full-field tomographic vibrometry in biological tissues.
作者信息
Choi Samuel, Sato Keita, Ota Takeru, Nin Fumiaki, Muramatsu Shogo, Hibino Hiroshi
机构信息
Niigata University, Department of Electrical and Electronics Engineering, 8050 Ikarashi-2, Niigata 950-2181, Japan; AMED-CTRST, AMED, Japan.
Niigata University, Department of Electrical and Electronics Engineering, 8050 Ikarashi-2, Niigata 950-2181, Japan.
出版信息
Biomed Opt Express. 2017 Jan 6;8(2):608-621. doi: 10.1364/BOE.8.000608. eCollection 2017 Feb 1.
Abstract
Because conventional laser Doppler vibrometry or Doppler optical coherence tomography require mechanical scanning probes that cannot simultaneously measure the wide-range dynamics of bio-tissues, a multifrequency-swept optical coherence microscopy with wide-field heterodyne detection technique was developed. A 1024 × 1024 × 2000 voxel volume was acquired with an axial resolution of ~1.8 μm and an acquisition speed of 2 s. Vibration measurements at 10 kHz were performed over a wide field of view. Wide-field tomographic vibration measurements of a mouse tympanic membrane are demonstrated to illustrate the applicability of this method to live animals.
摘要
由于传统的激光多普勒振动测量法或多普勒光学相干断层扫描需要机械扫描探头，无法同时测量生物组织的大范围动态，因此开发了一种具有宽场外差检测技术的多频扫描光学相干显微镜。采集了一个1024×1024×2000体素的体积，轴向分辨率约为1.8μm，采集速度为2秒。在10kHz下对宽视场进行了振动测量。展示了对小鼠鼓膜的宽场断层振动测量，以说明该方法对活体动物的适用性。
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