糖皮质激素与生殖：通往生殖之路的交通管制
Glucocorticoids and Reproduction: Traffic Control on the Road to Reproduction.
作者信息
Whirledge Shannon, Cidlowski John A
机构信息
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA.
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
出版信息
Trends Endocrinol Metab. 2017 Jun;28(6):399-415. doi: 10.1016/j.tem.2017.02.005. Epub 2017 Mar 6.
Glucocorticoids are steroid hormones that regulate diverse cellular functions and are essential to facilitate normal physiology. However, stress-induced levels of glucocorticoids result in several pathologies including profound reproductive dysfunction. Compelling new evidence indicates that glucocorticoids are crucial to the establishment and maintenance of reproductive function. The fertility-promoting or -inhibiting activity of glucocorticoids depends on timing, dose, and glucocorticoid responsiveness within a given tissue, which is mediated by the glucocorticoid receptor (GR). The GR gene and protein are subject to cellular processing, contributing to signaling diversity and providing a mechanism by which both physiological and stress-induced levels of glucocorticoids function in a cell-specific manner. Understanding how glucocorticoids regulate fertility and infertility may lead to novel approaches to the regulation of reproductive function.
糖皮质激素是调节多种细胞功能的类固醇激素，对促进正常生理功能至关重要。然而，应激诱导的糖皮质激素水平会导致多种病理状况，包括严重的生殖功能障碍。新的有力证据表明，糖皮质激素对生殖功能的建立和维持至关重要。糖皮质激素的促生育或抑制生育活性取决于时间、剂量以及特定组织内的糖皮质激素反应性，这是由糖皮质激素受体（GR）介导的。GR基因和蛋白会经历细胞加工过程，从而导致信号多样性，并提供一种机制，使生理水平和应激诱导水平的糖皮质激素以细胞特异性方式发挥作用。了解糖皮质激素如何调节生育和不育可能会带来调节生殖功能的新方法。
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