Bassi da Silva Jéssica, Ferreira Sabrina Barbosa de Souza, de Freitas Osvaldo, Bruschi Marcos Luciano
a Postgraduate Program in Pharmaceutical Sciences , Laboratory of Research and Development of Drug Delivery Systems, Department of Pharmacy, State University of Maringá , Maringá , Paran´ , Brazil.
b Department of Pharmaceutical Sciences, Ribeirão Preto School of Pharmaceutical Sciences, University of São Paulo , São Paulo , Brazil.
Drug Dev Ind Pharm. 2017 Jul;43(7):1053-1070. doi: 10.1080/03639045.2017.1294600. Epub 2017 Mar 1.
Mucoadhesion is a useful strategy for drug delivery systems, such as tablets, patches, gels, liposomes, micro/nanoparticles, nanosuspensions, microemulsions and colloidal dispersions. Moreover, it has contributed to many benefits like increased residence time at application sites, drug protection, increased drug permeation and improved drug availability. In this context, investigation into the mucoadhesive properties of pharmaceutical dosage forms is fundamental, in order to characterize, understand and simulate the in vivo interaction between the formulation and the biological substrate, contributing to the development of new mucoadhesive systems with effectiveness, safety and quality. There are a lot of in vivo, in vitro and ex vivo methods for the evaluation of the mucoadhesive properties of drug delivery systems. However, there also is a lack of standardization of these techniques, which makes comparison between the results difficult. Therefore, this work aims to show an overview of the most commonly employed methods for mucoadhesion evaluation, relating them to different proposed systems and using artificial or natural mucosa from humans and animals.
粘膜粘附是药物递送系统的一种有用策略，这些系统包括片剂、贴剂、凝胶、脂质体、微/纳米颗粒、纳米混悬液、微乳剂和胶体分散体。此外，它带来了许多益处，如在应用部位的停留时间增加、药物保护、药物渗透增加以及药物可用性提高。在此背景下，研究药物剂型的粘膜粘附特性至关重要，以便表征、理解和模拟制剂与生物底物之间的体内相互作用，有助于开发具有有效性、安全性和质量的新型粘膜粘附系统。有许多体内、体外和离体方法可用于评估药物递送系统的粘膜粘附特性。然而，这些技术也缺乏标准化，这使得结果之间的比较变得困难。因此，这项工作旨在概述最常用的粘膜粘附评估方法，将它们与不同的提议系统相关联，并使用来自人和动物的人工或天然粘膜。
