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乳腺癌合并泌乳素瘤:一例报告。

Breast carcinoma associated with prolactinoma: A case report.

作者信息

Zheng Yurong, Mo Wenju, Yu Yang, Zou Dehong, He Xiangming, Xia Xianghou, Hu Jiejie

机构信息

a Department of Breast Surgery , Zhejiang Cancer Hospital , Hangzhou , China.

出版信息

Cancer Biol Ther. 2017 Mar 4;18(3):132-136. doi: 10.1080/15384047.2017.1294284. Epub 2017 Feb 17.

DOI:10.1080/15384047.2017.1294284
PMID:28278079
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5389425/
Abstract

We report a 28-year-old woman who presented with a 6-year history of milk-like discharge from both of her nipples and was diagnosed with prolactinoma based on computed tomography (CT) findings and serum prolactin level. Further breast examination revealed a mass located in the upper outer region of the left breast. She underwent subtotal pituitary tumor resection. Thereafter, modified radical mastectomy was performed for left breast cancer. Twelve years after treatment, prolactinoma recurrence was detected, and bromocriptine therapy was administered. No recurrence of breast cancer was discovered. Based on this case report, we stress the importance of prolactin levels due to their possible biologic effects on breast cancer induction or growth.

摘要

我们报告一名28岁女性,她有6年双侧乳头出现乳样溢液的病史,根据计算机断层扫描(CT)结果和血清催乳素水平被诊断为催乳素瘤。进一步的乳房检查发现左乳房外上区域有一个肿块。她接受了垂体肿瘤次全切除术。此后,对左乳腺癌进行了改良根治性乳房切除术。治疗12年后,检测到催乳素瘤复发,并给予溴隐亭治疗。未发现乳腺癌复发。基于本病例报告,我们强调催乳素水平的重要性,因为它们可能对乳腺癌的诱发或生长产生生物学影响。

相似文献

1
Breast carcinoma associated with prolactinoma: A case report.乳腺癌合并泌乳素瘤:一例报告。
Cancer Biol Ther. 2017 Mar 4;18(3):132-136. doi: 10.1080/15384047.2017.1294284. Epub 2017 Feb 17.
2
Breast cancer in a male patient with prolactinoma.一名患有泌乳素瘤的男性患者患乳腺癌。
Surg Today. 1993;23(3):251-5. doi: 10.1007/BF00309236.
3
What causes a prolactinoma to be aggressive or to become a pituitary carcinoma?是什么导致泌乳素瘤具有侵袭性或变成垂体癌?
Hormones (Athens). 2012 Oct-Dec;11(4):477-82. doi: 10.14310/horm.2002.1380.
4
Pituitary prolactin-secreting macroadenoma combined with bilateral breast cancer in a 45-year-old male.一名45岁男性患垂体泌乳素分泌型大腺瘤合并双侧乳腺癌。
J Endocrinol Invest. 2001 Jun;24(6):454-9. doi: 10.1007/BF03351047.
5
A rare case of invasive ductal carcinoma with hyperprolactinemia.一例罕见的伴有高催乳素血症的浸润性导管癌病例。
Breast Cancer. 2007;14(3):302-6. doi: 10.2325/jbcs.14.302.
6
Rapid re-enlargement of a macroprolactinoma after initial shrinkage in a young woman treated with bromocriptine.一名年轻女性在接受溴隐亭治疗后,大泌乳素瘤最初缩小,之后迅速再次增大。
Gynecol Endocrinol. 2005 Jun;20(6):317-21. doi: 10.1080/09513590500098034.
7
A case of an ectopic prolactinoma.一例异位催乳素瘤。
Gynecol Endocrinol. 2012 Feb;28(2):148-9. doi: 10.3109/09513590.2011.589923. Epub 2011 Jul 23.
8
Gangliocytoma masquerading as a prolactinoma. Case report.伪装成催乳素瘤的神经节细胞瘤。病例报告。
J Neurosurg. 1999 Sep;91(3):490-5. doi: 10.3171/jns.1999.91.3.0490.
9
A null cell adenoma of the pituitary detected seven years after removal of a prolactinoma. Recurrence or de novo tumourigenesis?催乳素瘤切除七年后发现的垂体无细胞瘤。是复发还是新发肿瘤?
Acta Endocrinol (Copenh). 1991 Dec;125(6):700-4. doi: 10.1530/acta.0.1250700.
10
The hook effect in prolactin immunoassays.催乳素免疫测定中的钩状效应。
Saudi Med J. 2004 May;25(5):656-9.

引用本文的文献

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Hyperprolactinemia and cancer risk: a Swedish population-based cohort study.高催乳素血症与癌症风险:一项基于瑞典人群的队列研究。
Endocr Connect. 2025 Jun 19;14(6). doi: 10.1530/EC-25-0108. Print 2025 Jun 1.
2
Breast Cancer risk in patients with dopamine agonist-treated hyperprolactinemia.多巴胺激动剂治疗的高泌乳素血症患者的乳腺癌风险
J Endocrinol Invest. 2025 Mar;48(3):691-699. doi: 10.1007/s40618-024-02492-2. Epub 2024 Oct 30.
3
Pituitary tumors and the risk of other malignancies: is the relationship coincidental or causal?垂体瘤与其他恶性肿瘤的风险:这种关系是巧合还是因果关系?
Endocr Oncol. 2022 Dec 22;2(1):R1-R13. doi: 10.1530/EO-21-0033. eCollection 2022 Jan.
4
Breast Cancer and Prolactin - New Mechanisms and Models.乳腺癌与催乳素:新机制与新模型。
Endocrinology. 2022 Oct 1;163(10). doi: 10.1210/endocr/bqac122.
5
Giant prolactinoma, germline BRCA1 mutation, and depression: a case report.巨大泌乳素瘤、生殖系BRCA1突变与抑郁症:一例报告
J Med Case Rep. 2018 Dec 6;12(1):360. doi: 10.1186/s13256-018-1890-x.

本文引用的文献

1
Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers.性激素依赖性的tRNA半体可增强乳腺癌和前列腺癌中的细胞增殖。
Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3816-25. doi: 10.1073/pnas.1510077112. Epub 2015 Jun 29.
2
Modeling prolactin actions in breast cancer in vivo: insights from the NRL-PRL mouse.在体内模拟催乳素在乳腺癌中的作用:来自NRL-PRL小鼠的见解。
Adv Exp Med Biol. 2015;846:201-20. doi: 10.1007/978-3-319-12114-7_9.
3
A 20-year prospective study of plasma prolactin as a risk marker of breast cancer development.一项针对血浆催乳素作为乳腺癌发展风险标志物的 20 年前瞻性研究。
Cancer Res. 2013 Aug 1;73(15):4810-9. doi: 10.1158/0008-5472.CAN-13-0665. Epub 2013 Jun 19.
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Global profiling of prolactin-modulated transcripts in breast cancer in vivo.体内乳腺癌中催乳素调节转录本的全局分析。
Mol Cancer. 2013 Jun 12;12:59. doi: 10.1186/1476-4598-12-59.
5
Prolactin suppresses a progestin-induced CK5-positive cell population in luminal breast cancer through inhibition of progestin-driven BCL6 expression.催乳素通过抑制孕激素驱动的BCL6表达,抑制腔面型乳腺癌中孕激素诱导的CK5阳性细胞群。
Oncogene. 2014 Apr 24;33(17):2215-24. doi: 10.1038/onc.2013.172. Epub 2013 May 27.
6
Progesterone signalling in breast cancer: a neglected hormone coming into the limelight.孕激素在乳腺癌中的信号转导:一种被忽视的激素逐渐成为焦点。
Nat Rev Cancer. 2013 Jun;13(6):385-96. doi: 10.1038/nrc3518.
7
Giant prolactinoma: case report and review of literature.巨大泌乳素瘤:病例报告及文献综述
J Diabetes Metab Disord. 2013 Jan 8;12(1):3. doi: 10.1186/2251-6581-12-3.
8
The global breast cancer burden.全球乳腺癌负担。
Future Oncol. 2012 Jun;8(6):697-702. doi: 10.2217/fon.12.61.
9
Acromegaly due to an ectopic pituitary adenoma in the clivus: case report and review of literature.鞍区异位垂体腺瘤致肢端肥大症 1 例报告并文献复习
Pituitary. 2012 Dec;15 Suppl 1:S53-6. doi: 10.1007/s11102-011-0345-9.
10
Cancer risk in hyperprolactinemia patients: a population-based cohort study.高泌乳素血症患者的癌症风险:基于人群的队列研究。
Eur J Endocrinol. 2011 Aug;165(2):209-15. doi: 10.1530/EJE-11-0076. Epub 2011 May 20.