Wolf Ingrid-Katharina, Du Yong, Knopf Hildtraud
Department of Epidemiology and Health Monitoring, Robert Koch Institute, General-Pape-Str. 64-66, D-12101, Berlin, Germany.
BMC Psychiatry. 2017 Mar 9;17(1):90. doi: 10.1186/s12888-017-1254-x.
Psychotropic drug use and alcohol consumption among older adults need to be monitored over time as their use or combined use bears risks of harms. Representative data on changes in prevalence, patterns and co-relates of substance use are lacking in Germany.
Participants were older adults (60-79 years) from two German National Health Surveys: 1997-99 (GNHIES98, N = 1,606) and 2008-11 (DEGS1, N = 2,501). Included were drugs acting on the nervous system used during the last 7 days. Alcohol consumption was measured by frequency (daily drinking) and quantity (risky drinking: ≥20/10 g/day alcohol for men/women). Changes in prevalence adjusted for potential socio-economic and health-related confounders were calculated by logistic regression models approximated by the SAS LSMEANS statement.
The prevalence of overall psychotropic drug use (20.5% vs. 21.4%) remained constant between the two surveys. Significant changes were observed in the use of some psychotropics (all GNHIES98 vs. DEGS1): Synthetic antidepressants (3.9% vs. 6.9%), St. John's wort (2.9% vs. 1.1%), benzodiazepines (3.7% vs. 2.5%), benzodiazepine related drugs (0.2% vs. 0.8%), narcotic analgesics (3.0% vs. 4.1%), anti-dementia drugs (2.2% vs. 4.2%) and anti-epileptics (1.0% vs. 2.3%). Significant changes were also observed in long-term use of synthetic anti-depressants (3.2% vs. 5.9%), St. John's wort (2.0% vs. 0.6%) and opioid analgesics (1.0% vs. 2.2%). Further, we found significant changes in benzodiazepines use (3.3% vs. 1.4%) among men, opioids use (2.9% vs. 7.3%) among people with a lower social status, and overall psychotropics (26.8% vs. 32.5%) as well as opioids use (4.4% vs. 8.1%) among those with a worse health status. Moderate alcohol consumption increased significantly (58.0% vs. 66.9%). Risky drinking remained unchanged (16.6% vs. 17.0%). In spite of significant increases in daily alcohol drinking (13.2% vs. 18.4%) psychotropic drug use combined with daily drinking remained unchanged (1.8% vs. 2.7%).
Although prevalence of overall psychotropic drug use remained stable, changes in the use of some psychotropic drug groups and alcohol consumption patterns have been observed. Further studies are required to investigate resulting health consequences and public health relevance of those outcomes.
老年人使用精神药物和饮酒情况需要长期监测,因为单独使用或联合使用这些物质存在有害风险。德国缺乏关于物质使用流行率、模式及其相关因素变化的代表性数据。
参与者为来自两项德国国民健康调查的老年人(60 - 79岁):1997 - 1999年(德国国民健康访谈与检查调查98,GNHIES98,N = 1606)和2008 - 2011年(德国健康访谈与检查调查1,DEGS1,N = 2501)。纳入过去7天内使用的作用于神经系统的药物。饮酒情况通过频率(每日饮酒)和量(危险饮酒:男性/女性每日酒精摄入量≥20/10克)来衡量。通过SAS LSMEANS语句近似的逻辑回归模型计算调整潜在社会经济和健康相关混杂因素后的流行率变化。
两次调查之间,总体精神药物使用流行率(20.5%对21.4%)保持不变。在某些精神药物的使用方面观察到显著变化(均为GNHIES98对DEGS1):合成抗抑郁药(3.9%对6.9%)、圣约翰草(2.9%对1.1%)、苯二氮䓬类药物(3.7%对2.5%)、苯二氮䓬类相关药物(0.2%对0.8%)、麻醉性镇痛药(3.0%对4.1%)、抗痴呆药(2.2%对4.2%)和抗癫痫药(1.0%对2.3%)。在合成抗抑郁药(3.2%对5.9%)、圣约翰草(2.0%对0.6%)和阿片类镇痛药(1.0%对2.2%)的长期使用方面也观察到显著变化。此外,我们发现男性中苯二氮䓬类药物使用(3.3%对1.4%)、社会地位较低者中阿片类药物使用(2.9%对7.3%)、健康状况较差者中总体精神药物使用(26.8%对32.5%)以及阿片类药物使用(4.4%对8.1%)存在显著变化。适度饮酒显著增加(58.0%对66.9%)。危险饮酒保持不变(16.6%对17.0%)。尽管每日饮酒量显著增加(13.2%对18.4%),但精神药物使用与每日饮酒联合使用情况保持不变(1.8%对2.7%)。
尽管总体精神药物使用流行率保持稳定,但已观察到某些精神药物组的使用情况和饮酒模式发生了变化。需要进一步研究以调查这些结果所导致的健康后果及公共卫生相关性。