Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
General Practice Research Unit, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
PLoS One. 2019 Apr 16;14(4):e0214813. doi: 10.1371/journal.pone.0214813. eCollection 2019.
The aim of this study was to investigate whether frequent drinking, use of drugs with addiction potential and the possible combination of frequent drinking and use of prescribed drugs with addiction potential were associated with all-cause mortality in older adults.
We used data from the Nord-Trøndelag Health Study (HUNT3 2006-08), a population-based study in Norway. A total of 11,545 (6,084 women) individuals 65 years and older at baseline participated. We assessed frequent drinking (≥ 4 days a week), occasional drinking (i.e. a few times a year), never drinking and non-drinking in the last year. Drugs with addiction potential were defined as at least one prescription of benzodiazepines, z-hypnotics or opioids during one year for a minimum of two consecutive years between 2005 and 2009. This information was drawn from the Norwegian Prescription Database. The main outcome was all-cause mortality with information drawn from the Norwegian Cause of Death Registry. Follow-up continued until death or latest at 31 December 2013. Logistic regression analyses were used to investigate all-cause mortality since date of study entry and exact age at time of death was unknown.
The adjusted logistic regression analyses showed that frequent drinking was not associated with all-cause mortality compared to occasional drinking. Men who reported to be never drinkers and non-drinkers in the last year had higher odds of mortality compared to those who drank occasionally. Use of prescribed drugs with addiction potential was associated with increased mortality in men, but not in women. No association was found between the possible combination of frequent drinking and use of prescribed drugs with addiction potential and mortality.
Neither frequent drinking nor the possible combination of frequent drinking and use of prescribed drugs with addiction potential were associated with all-cause mortality in older women and men. Use of prescribed drugs with addiction potential was associated with higher odds of mortality in men. This finding should lead to more caution in prescribing drugs with addiction potential to this group.
本研究旨在探讨老年人中频繁饮酒、使用具有成瘾潜力的药物以及频繁饮酒和使用具有成瘾潜力的处方药物的可能组合是否与全因死亡率相关。
我们使用了来自挪威的基于人群的 Nord-Trøndelag 健康研究（HUNT3 2006-08）的数据。共有 11545 名（6084 名女性）65 岁及以上的基线参与者。我们评估了频繁饮酒（≥4 天/周）、偶尔饮酒（即每年几次）、从不饮酒和过去一年不饮酒的情况。具有成瘾潜力的药物被定义为在 2005 年至 2009 年期间，至少有一次在一年中连续两年至少开了两次苯二氮䓬类、Z 类催眠药或阿片类药物的处方。这些信息是从挪威处方数据库中提取的。主要结局是全因死亡率，信息来自挪威死因登记处。随访时间截止至死亡或截至 2013 年 12 月 31 日。使用逻辑回归分析来研究自研究开始日期起的全因死亡率，且确切的死亡年龄未知。
调整后的逻辑回归分析表明，与偶尔饮酒相比，频繁饮酒与全因死亡率无关。报告在过去一年中从不饮酒和不饮酒的男性与偶尔饮酒者相比，死亡的几率更高。使用具有成瘾潜力的处方药物与男性死亡率增加有关，但与女性无关。在频繁饮酒和使用具有成瘾潜力的处方药物的可能组合与死亡率之间未发现关联。
在老年女性和男性中，无论是频繁饮酒还是频繁饮酒和使用具有成瘾潜力的处方药物的可能组合，都与全因死亡率无关。使用具有成瘾潜力的处方药物与男性死亡率增加有关。这一发现应该导致在给这一人群开具有成瘾潜力的药物时更加谨慎。
