Hall Alexander Mj, Gollan Bridget, Helaine Sophie
MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.
MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.
Curr Opin Microbiol. 2017 Apr;36:102-110. doi: 10.1016/j.mib.2017.02.003. Epub 2017 Mar 6.
Toxin-antitoxin (TA) systems encoded on the plasmids and chromosomes of bacteria are emerging as key players in stress adaptation. In particular, they have been implicated in the induction of persisters non-growing cells that can evade antibiotic exposure. TA toxins operate by a diverse range of mechanisms, either destructive or conservative, leading to the reversible growth arrest of bacterial cells. Whilst the molecular mechanisms of intoxication are now well understood, we still have very little information on how corrupted cells reawaken. Alongside the phenomenon of conditional cooperativity, new evidence suggests that the effects of some TA toxins can be reversed, allowing non-growing cells to be detoxified and growth to resume.
细菌质粒和染色体上编码的毒素-抗毒素（TA）系统正逐渐成为应激适应中的关键因素。特别是，它们与诱导能够逃避抗生素作用的非生长状态的持留菌有关。TA毒素通过多种机制发挥作用，既有破坏性的，也有保守性的，导致细菌细胞可逆性生长停滞。虽然目前对中毒的分子机制已经有了很好的了解，但我们对受损细胞如何重新苏醒仍然知之甚少。除了条件性协同现象外，新证据表明一些TA毒素的作用可以逆转，使非生长细胞解毒并恢复生长。
