Inserm, BRM (Bacterial Regulatory RNAs and Medicine), - UMR_S 1230, 35000 Rennes, France.
Inserm, BRM (Bacterial Regulatory RNAs and Medicine), - UMR_S 1230, 35000 Rennes, France.
Trends Microbiol. 2020 Oct;28(10):851-866. doi: 10.1016/j.tim.2020.05.016. Epub 2020 Jun 12.
Toxin-antitoxin (TA) systems are ubiquitous among bacteria and include stable toxins whose toxicity can be counteracted by RNA or protein antitoxins. They are involved in multiple functions that range from stability maintenance for mobile genetic elements to stress adaptation. Bacterial chromosomes frequently have multiple homologues of TA system loci, and it is unclear why there are so many of them. In this review we focus on cross-regulations between TA systems, which occur between both homologous and nonhomologous systems, from similar or distinct types, whether encoded from plasmids or chromosomes. In addition to being able to modulate RNA expression levels, cross-regulations between these systems can also influence their toxicity. This suggests the idea that they are involved in an interconnected regulatory network.
毒素-抗毒素（TA）系统在细菌中普遍存在，包括稳定的毒素，其毒性可以被 RNA 或蛋白质抗毒素中和。它们参与多种功能，从移动遗传元件的稳定性维持到应激适应。细菌染色体通常具有多个 TA 系统基因座的同源物，目前尚不清楚为什么会有这么多同源物。在这篇综述中，我们重点关注 TA 系统之间的交叉调控，这些调控发生在同源和非同源系统之间，来自相似或不同类型的系统，无论是来自质粒还是染色体。除了能够调节 RNA 表达水平外，这些系统之间的交叉调控还可以影响它们的毒性。这表明它们参与了一个相互关联的调控网络。
