He Zhili, Wang Hui
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100071, China.
Sheng Wu Gong Cheng Xue Bao. 2018 Aug 25;34(8):1270-1278. doi: 10.13345/j.cjb.170527.
TA (Toxin-Antitoxin) systems are widely spread in chromosomes and plasmids of bacteria and archaea. These systems consist of two co-expression genes, encoding stable toxin and sensitive antitoxin, respectively. The toxicity of toxins usually inhibits bacterial growth and antitoxins can neutralize the toxins. Interaction between them would regulate the growth state of bacteria precisely. According to the composition of TA and nature of antitoxin, six types of TA have been found. The role of these TA systems in bacteria has been a hot research topic in recent years. Now, the research status on functions of bacterial TA is reviewed.
毒素-抗毒素（TA）系统广泛存在于细菌和古菌的染色体及质粒中。这些系统由两个共表达基因组成，分别编码稳定的毒素和敏感的抗毒素。毒素的毒性通常会抑制细菌生长，而抗毒素可中和毒素。它们之间的相互作用能精确调控细菌的生长状态。根据TA的组成和抗毒素的性质，已发现六种类型的TA。近年来，这些TA系统在细菌中的作用一直是研究热点。现将细菌TA功能的研究现状进行综述。
