In vitro BALB/3T3 cell transformation assay of nonoxynol-9 and 1,4-dioxane.
作者信息
Sheu C W, Moreland F M, Lee J K, Dunkel V C
机构信息
Genetic Toxicology Branch, Food and Drug Administration, Washington, DC 20204.
出版信息
Environ Mol Mutagen. 1988;11(1):41-8. doi: 10.1002/em.2850110106.
PMID:2828043
Abstract
The spermicidal surfactant nonoxynol-9 (Igepal CO-630, GAF Corp.) and a potential impurity, 1,4-dioxane, were tested in the in vitro cell transformation assay using BALB/3T3 cells. Two treatment periods, 48 hr and 13 days, were used. Nonoxynol-9, tested at levels up to 10 micrograms/ml, did not induce transformation, whereas dioxane was very active in the induction of type III foci in the cultured BALB/3T3 cells.
摘要
相似文献
1
In vitro BALB/3T3 cell transformation assay of nonoxynol-9 and 1,4-dioxane.
Environ Mol Mutagen. 1988;11(1):41-8. doi: 10.1002/em.2850110106.
2
Effect of nonoxynol-9, a detergent with spermicidal activity, on malignant transformation in vitro.
Carcinogenesis. 1982;3(5):553-7. doi: 10.1093/carcin/3.5.553.
3
Evaluation of the cytotoxicity and genotoxicity of the spermicides nonoxynol-9 and octoxynol-9.
Toxicol Lett. 1986 Apr;31(1):65-73. doi: 10.1016/0378-4274(86)90195-5.
4
In vitro activity of nonoxynol 9 on HeLa 229 cells and primary monkey cervical epithelial cells infected with Chlamydia trachomatis.壬苯醇醚9对感染沙眼衣原体的HeLa 229细胞和原代猴宫颈上皮细胞的体外活性。
Antimicrob Agents Chemother. 1992 Jul;36(7):1478-82. doi: 10.1128/AAC.36.7.1478.
5
A modified transmembrane migration method for evaluating the spermicidal potency of some nonoxynol compounds.一种用于评估某些壬苯醇醚化合物杀精效力的改良跨膜迁移方法。
J Pharm Pharmacol. 1988 Mar;40(3):215-6. doi: 10.1111/j.2042-7158.1988.tb05225.x.
6
Teratogenicity and in vitro mutagenicity studies on nonoxynol-9 and -30.壬苯醇醚-9和-30的致畸性及体外诱变性研究。
Pharmacol Toxicol. 1988 Apr;62(4):236-8. doi: 10.1111/j.1600-0773.1988.tb01879.x.
7
Comparison of the spermicidal activity and acute toxicity of nonoxynol-9 and agent 741 [alkylphenoxy polyethoxy ethanol(10)].壬苯醇醚-9与741制剂[烷基苯氧基聚乙氧基乙醇(10)]的杀精活性及急性毒性比较。
Contraception. 1986 Jan;33(1):1-5. doi: 10.1016/0010-7824(86)90026-0.
8
Quantification of the in vitro activity of some compounds with spermicidal activity.一些具有杀精活性的化合物的体外活性定量分析。
Contraception. 1992 Dec;46(6):527-36. doi: 10.1016/0010-7824(92)90117-c.
9
Bioelectric activity as a quantifiable index of acute spermicide (nonoxynol-9) actions on rat vaginal epithelial function during the oestrous cycle.生物电活动作为急性杀精剂（壬苯醇醚-9）在发情周期对大鼠阴道上皮功能作用的可量化指标。
Pharmacol Toxicol. 1987 Mar;60(3):175-8. doi: 10.1111/j.1600-0773.1987.tb01728.x.
10
The inhibitory effect of spermicidal agents on replication of HSV-2 and HIV-1 in-vitro.杀精剂对单纯疱疹病毒2型和人类免疫缺陷病毒1型体外复制的抑制作用。
J Antimicrob Chemother. 1993 Jul;32(1):71-82. doi: 10.1093/jac/32.1.71.
Zotero 插件