乙醛慢性中毒会刺激大鼠肝脏中的胶原蛋白生物合成。
Chronic intoxication with acetaldehyde stimulates collagen biosynthesis in rat liver.
作者信息
Pawlicka E, Bańkowski E, Sobolewski K
机构信息
Department of Biochemistry, Medical Academy of Bialystok, Poland.
出版信息
Arch Toxicol. 1991;65(8):678-80. doi: 10.1007/BF02098036.
It was found that chronic intoxication of rats with acetaldehyde results in a distinct, progressive increase of 5(3)H-proline incorporation into collagen synthesized by liver. At the same time, biosynthesis of other proline-containing (noncollagenous) proteins does not change significantly. The effects are similar to those induced by chronic intoxication of rats with ethanol. Since acetaldehyde is an intermediary metabolite formed during ethanol oxidation in liver, it may be concluded that acetaldehyde is a factor responsible for alcohol-induced liver fibrosis.
研究发现，用乙醛对大鼠进行慢性中毒会导致肝脏合成的胶原蛋白中5(3)H-脯氨酸掺入量明显且逐渐增加。与此同时，其他含脯氨酸（非胶原蛋白）蛋白质的生物合成没有显著变化。这些影响与用乙醇对大鼠进行慢性中毒所诱导的影响相似。由于乙醛是肝脏中乙醇氧化过程中形成的中间代谢产物，因此可以得出结论，乙醛是酒精性肝纤维化的一个成因。
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