驻留唾液腺巨噬细胞在抗原依赖性T细胞增殖中起辅助细胞的作用。
Resident salivary gland macrophages function as accessory cells in antigen-dependent T-cell proliferation.
作者信息
Pappo J, Ebersole J L, Taubman M A
机构信息
Department of Immunology, Forsyth Dental Center, Boston, Massachusetts.
出版信息
Immunology. 1988 Jan;63(1):99-104.
Abstract
The function of salivary gland macrophages in the induction of local immunity in secretory organs was investigated in Fischer 344 rats. Macrophages obtained from dispersed submandibular gland (SMG) cells were characterized and examined for their ability to present antigen to T cells. Populations of SMG-adherent cells contained approximately 80% macrophages, of which 46-62% were I-A+ cells. These numbers were from five to 10-fold greater than the I-A+ cells in macrophage populations from peritoneal exudates (5-11%). SMG macrophages functioned effectively as antigen-presenting cells. Antigen presentation was antigen specific, macrophage dose dependent and inhibitable by monoclonal anti-I-A antibodies. These studies suggest that a functional salivary-gland immune-response pathway exists that can function independently of a gut-associated lymphocyte-homing mechanism.
摘要
在Fischer 344大鼠中研究了唾液腺巨噬细胞在分泌器官局部免疫诱导中的作用。对从分散的下颌下腺（SMG）细胞中获得的巨噬细胞进行了表征，并检测了它们将抗原呈递给T细胞的能力。SMG贴壁细胞群体中约80%为巨噬细胞，其中46 - 62%为I-A + 细胞。这些数字比腹膜渗出液巨噬细胞群体中的I-A + 细胞（5 - 11%）高5至10倍。SMG巨噬细胞作为抗原呈递细胞发挥有效作用。抗原呈递具有抗原特异性、巨噬细胞剂量依赖性，并可被单克隆抗I-A抗体抑制。这些研究表明存在一条功能性唾液腺免疫反应途径，其可独立于肠道相关淋巴细胞归巢机制发挥作用。
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