Björklund Anders, Lindvall Olle
Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund, Sweden.
Department of Clinical Sciences, and Lund Stem Cell Center, Division of Neurology, University Hospital, Lund, Sweden.
J Parkinsons Dis. 2017;7(s1):S21-S31. doi: 10.3233/JPD-179002.
The efforts to develop a dopamine cell replacement therapy for Parkinson's disease have spanned over more than three decades. Based on almost 10 years of transplantation studies in animal models, the first patients receiving grafts of fetal-derived dopamine neuroblasts were operated in Lund in 1987. Over the following two decades, a total of 18 patients were transplanted and followed closely by our team with mixed but also very encouraging results. In this article we tell the story of how the preclinical and clinical transplantation program in Lund evolved. We recall the excitement when we obtained the first evidence for survival and function of transplanted neurons in the diseased human brain. We also remember the setbacks that we have experienced during these 30 years and discuss the very interesting developments that are now taking place in this exciting field.
为帕金森病开发多巴胺细胞替代疗法的努力已经跨越了三十多年。基于在动物模型上近10年的移植研究，1987年在隆德，首批接受胎儿来源多巴胺神经母细胞移植的患者接受了手术。在接下来的二十年里，我们的团队共对18名患者进行了移植并密切随访，结果有好有坏，但也非常令人鼓舞。在本文中，我们讲述了隆德临床前和临床移植项目的发展历程。我们回忆起在患病的人类大脑中获得移植神经元存活和功能的首个证据时的兴奋之情。我们也铭记这30年来所经历的挫折，并讨论这个令人兴奋的领域目前正在发生的非常有趣的进展。
