• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

虾青素和维生素E治疗饮食诱导的非酒精性脂肪性肝炎小鼠的肝脏转录组谱

Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E.

作者信息

Kobori Masuko, Takahashi Yumiko, Sakurai Mutsumi, Ni Yinhua, Chen Guanliang, Nagashimada Mayumi, Kaneko Shuichi, Ota Tsuguhito

机构信息

Food Research Institute, National Agriculture and Food Resrach Organization, Tsukuba, Ibaraki 305-8642, Japan.

Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan.

出版信息

Int J Mol Sci. 2017 Mar 8;18(3):593. doi: 10.3390/ijms18030593.

DOI:10.3390/ijms18030593
PMID:28282876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5372609/
Abstract

Astaxanthin alleviates hepatic lipid accumulation and peroxidation, inflammation, and fibrosis in mice with high-cholesterol, high-cholate, and high-fat (CL) diet-induced nonalcoholic steatohepatitis (NASH) [...].

摘要

虾青素可减轻高胆固醇、高胆酸盐和高脂肪(CL)饮食诱导的非酒精性脂肪性肝炎(NASH)小鼠的肝脏脂质积累、过氧化、炎症和纤维化[……]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ed0/5372609/abcbe7ca6690/ijms-18-00593-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ed0/5372609/6a28a1eee1fa/ijms-18-00593-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ed0/5372609/eaace04c08c4/ijms-18-00593-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ed0/5372609/110bd1fb1327/ijms-18-00593-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ed0/5372609/2820e442e353/ijms-18-00593-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ed0/5372609/abcbe7ca6690/ijms-18-00593-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ed0/5372609/6a28a1eee1fa/ijms-18-00593-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ed0/5372609/eaace04c08c4/ijms-18-00593-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ed0/5372609/110bd1fb1327/ijms-18-00593-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ed0/5372609/2820e442e353/ijms-18-00593-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ed0/5372609/abcbe7ca6690/ijms-18-00593-g005.jpg

相似文献

1
Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E.虾青素和维生素E治疗饮食诱导的非酒精性脂肪性肝炎小鼠的肝脏转录组谱
Int J Mol Sci. 2017 Mar 8;18(3):593. doi: 10.3390/ijms18030593.
2
Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E.虾青素可预防并逆转小鼠饮食诱导的胰岛素抵抗和脂肪性肝炎:与维生素E的比较。
Sci Rep. 2015 Nov 25;5:17192. doi: 10.1038/srep17192.
3
Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening.依洛前列素,一种过氧化物酶体增殖物激活受体-α和-δ激动剂,可在不加重肝纤维化的情况下诱导非酒精性脂肪性肝炎消退。
Gastroenterology. 2016 May;150(5):1147-1159.e5. doi: 10.1053/j.gastro.2016.01.038. Epub 2016 Feb 11.
4
Elafibranor improves diet-induced nonalcoholic steatohepatitis associated with heart failure with preserved ejection fraction in Golden Syrian hamsters.依拉非尼可改善饮食诱导的、与金叙利亚仓鼠射血分数保留的心力衰竭相关的非酒精性脂肪性肝炎。
Metabolism. 2021 Apr;117:154707. doi: 10.1016/j.metabol.2021.154707. Epub 2021 Jan 11.
5
Inhibition of aldose reductase ameliorates diet-induced nonalcoholic steatohepatitis in mice via modulating the phosphorylation of hepatic peroxisome proliferator-activated receptor α.抑制醛糖还原酶通过调节肝脏过氧化物酶体增殖物激活受体α的磷酸化改善饮食诱导的小鼠非酒精性脂肪性肝炎。
Mol Med Rep. 2015 Jan;11(1):303-8. doi: 10.3892/mmr.2014.2713. Epub 2014 Oct 21.
6
The PPAR α/γ Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease.PPARα/γ 激动剂罗格列酮改善非酒精性脂肪性肝病动物模型的胰岛素抵抗和脂肪性肝炎。
Sci Rep. 2020 Jun 9;10(1):9330. doi: 10.1038/s41598-020-66458-z.
7
Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease.过氧化物酶体增殖物激活受体δ激动剂改善了非酒精性脂肪性肝病中的炎性小体激活。
World J Gastroenterol. 2015 Dec 7;21(45):12787-99. doi: 10.3748/wjg.v21.i45.12787.
8
Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, improves the pathogenesis in a rodent model of nonalcoholic steatohepatitis.非诺贝特,一种新型选择性过氧化物酶体增殖物激活受体α调节剂,改善非酒精性脂肪性肝炎啮齿动物模型中的发病机制。
Sci Rep. 2017 Feb 14;7:42477. doi: 10.1038/srep42477.
9
Metabolic and hepatic effects of liraglutide, obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis.利拉鲁肽、奥贝胆酸和 Elafibranor 在经活检证实的非酒精性脂肪性肝炎肥胖小鼠模型中的代谢和肝脏作用。
World J Gastroenterol. 2018 Jan 14;24(2):179-194. doi: 10.3748/wjg.v24.i2.179.
10
Sesamin ameliorates hepatic steatosis and inflammation in rats on a high-fat diet via LXRα and PPARα.芝麻素通过肝X受体α(LXRα)和过氧化物酶体增殖物激活受体α(PPARα)改善高脂饮食大鼠的肝脏脂肪变性和炎症。
Nutr Res. 2016 Sep;36(9):1022-1030. doi: 10.1016/j.nutres.2016.06.015. Epub 2016 Jun 27.

引用本文的文献

1
Effects of on growth performance, hepatopancreatic transcriptome and resistance to ammonia-nitrogen stress of pacific white shrimp ().对凡纳滨对虾生长性能、肝胰腺转录组及氨氮胁迫抗性的影响。 (注:原文中“Effects of on...”部分有缺失内容)
Anim Nutr. 2025 Apr 24;22:337-351. doi: 10.1016/j.aninu.2025.03.007. eCollection 2025 Sep.
2
Effectiveness of Astaxanthin as a Feed Supplement to Improve Growth Performance and Feed Utilization in Aquaculture Animals: A Meta-Analysis.虾青素作为饲料添加剂对提高水产养殖动物生长性能和饲料利用率的有效性:一项荟萃分析。
Antioxidants (Basel). 2025 May 19;14(5):609. doi: 10.3390/antiox14050609.
3

本文引用的文献

1
The Potential of Non-Provitamin A Carotenoids for the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease.非维生素A类胡萝卜素在预防和治疗非酒精性脂肪性肝病中的潜力
Biology (Basel). 2016 Nov 8;5(4):42. doi: 10.3390/biology5040042.
2
Astaxanthin as a Potential Protector of Liver Function: A Review.虾青素作为肝功能潜在保护剂的综述
J Clin Med Res. 2016 Oct;8(10):701-4. doi: 10.14740/jocmr2672w. Epub 2016 Aug 30.
3
Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease.微量营养素抗氧化剂与非酒精性脂肪性肝病
The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive Review.
虾青素对代谢综合征的影响:一项综合综述。
Mar Drugs. 2024 Dec 27;23(1):9. doi: 10.3390/md23010009.
4
Preventative and Therapeutic Effects of Astaxanthin on NAFLD.虾青素对非酒精性脂肪性肝病的预防和治疗作用
Antioxidants (Basel). 2023 Aug 3;12(8):1552. doi: 10.3390/antiox12081552.
5
Terpenoids: Natural Compounds for Non-Alcoholic Fatty Liver Disease (NAFLD) Therapy.萜类化合物:非酒精性脂肪性肝病 (NAFLD) 治疗的天然化合物。
Molecules. 2022 Dec 29;28(1):272. doi: 10.3390/molecules28010272.
6
Key hepatic signatures of human and mouse nonalcoholic steatohepatitis: A transcriptome-proteome data meta-analysis.人类和小鼠非酒精性脂肪性肝炎的关键肝脏特征:转录组-蛋白质组数据分析荟萃分析。
Front Endocrinol (Lausanne). 2022 Oct 4;13:934847. doi: 10.3389/fendo.2022.934847. eCollection 2022.
7
Signature of gene expression profile of liver sinusoidal endothelial cells in nonalcoholic steatohepatitis.非酒精性脂肪性肝炎中肝窦内皮细胞基因表达谱的特征
Front Cell Dev Biol. 2022 Sep 21;10:946566. doi: 10.3389/fcell.2022.946566. eCollection 2022.
8
Astaxanthin From Prevents High-Fat Diet-Induced Hepatic Steatosis and Oxidative Stress in Mice by Gut-Liver Axis Modulating Properties.虾青素通过调节肠-肝轴特性预防高脂饮食诱导的小鼠肝脏脂肪变性和氧化应激。
Front Nutr. 2022 Apr 12;9:840648. doi: 10.3389/fnut.2022.840648. eCollection 2022.
9
Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19.天然虾青素在减轻新冠病毒感染中细胞因子风暴风险方面的潜力。
Biomed Pharmacother. 2020 Dec;132:110886. doi: 10.1016/j.biopha.2020.110886. Epub 2020 Oct 16.
10
Astaxanthin in Liver Health and Disease: A Potential Therapeutic Agent.虾青素在肝脏健康与疾病中的作用:一种潜在的治疗剂。
Drug Des Devel Ther. 2020 Jun 9;14:2275-2285. doi: 10.2147/DDDT.S230749. eCollection 2020.
Int J Mol Sci. 2016 Aug 23;17(9):1379. doi: 10.3390/ijms17091379.
4
Novel Action of Carotenoids on Non-Alcoholic Fatty Liver Disease: Macrophage Polarization and Liver Homeostasis.类胡萝卜素对非酒精性脂肪性肝病的新作用:巨噬细胞极化与肝脏稳态
Nutrients. 2016 Jun 24;8(7):391. doi: 10.3390/nu8070391.
5
Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E.虾青素可预防并逆转小鼠饮食诱导的胰岛素抵抗和脂肪性肝炎:与维生素E的比较。
Sci Rep. 2015 Nov 25;5:17192. doi: 10.1038/srep17192.
6
Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases.慢性肝病中Myc与炎症介质之间的相互作用
Mediators Inflamm. 2015;2015:276850. doi: 10.1155/2015/276850. Epub 2015 Oct 5.
7
Marine Carotenoids against Oxidative Stress: Effects on Human Health.海洋类胡萝卜素对抗氧化应激:对人类健康的影响。
Mar Drugs. 2015 Sep 30;13(10):6226-46. doi: 10.3390/md13106226.
8
Carotenoids from Marine Microalgae: A Valuable Natural Source for the Prevention of Chronic Diseases.来自海洋微藻的类胡萝卜素:预防慢性疾病的宝贵天然来源。
Mar Drugs. 2015 Aug 14;13(8):5128-55. doi: 10.3390/md13085128.
9
Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia.小儿急性髓系白血病中IKZF1的复发性缺失
Haematologica. 2015 Sep;100(9):1151-9. doi: 10.3324/haematol.2015.124321. Epub 2015 Jun 11.
10
Lipid profile and glucose changes after supplementation with astaxanthin: a systematic review and meta-analysis of randomized controlled trials.补充虾青素后血脂和血糖的变化:一项随机对照试验的系统评价和荟萃分析
Arch Med Sci. 2015 Apr 25;11(2):253-66. doi: 10.5114/aoms.2015.50960. Epub 2015 Apr 23.