Wang Meng, Xu Wenxin, Yu Jie, Liu Yingying, Ma Haotian, Ji Chunli, Zhang Chunhui, Xue Jinai, Li Runzhi, Cui Hongli
College of Agriculture, Institute of Molecular Agriculture and Bioenergy, Shanxi Agricultural University, Jinzhong, China.
Health Science Center, College of Forensic Sciences, Xi'an Jiaotong University, Xi'an, China.
Front Nutr. 2022 Apr 12;9:840648. doi: 10.3389/fnut.2022.840648. eCollection 2022.
Evidence is mounting that astaxanthin (ATX), a xanthophyll carotenoid, used as a nutritional supplement to prevent chronic metabolic diseases. The present study aims to identify the potential function of ATX supplementation in preventing steatohepatitis and hepatic oxidative stress in diet-induced obese mice.
In this study, ATX as dose of 0.25, 0.5, and 0.75% have orally administered to mice along with a high-fat diet (HFD) to investigate the role of ATX in regulating liver lipid metabolism and gut microbiota. The study showed that ATX dose-dependently reduces body weight, lipid droplet formation, hepatic triglycerides and ameliorated hepatic steatosis and oxidative stress. 0.75% ATX altered the levels of 34 lipid metabolites related to hepatic cholesterol and fatty acid metabolism which might be associated with downregulation of lipogenesis-related genes and upregulation of bile acid biosynthesis-related genes. The result also revealed that ATX alleviates HFD-induced gut microbiota dysbiosis by significantly inhibiting the growth of obesity-related and while promoting the growth of and .
The study results suggested that dietary ATX may prevent the development of hepatic steatosis and oxidative stress with the risk of metabolic disease by gut-liver axis modulating properties.
越来越多的证据表明，虾青素（ATX），一种叶黄素类胡萝卜素，用作预防慢性代谢疾病的营养补充剂。本研究旨在确定补充ATX在预防饮食诱导的肥胖小鼠肝脂肪变性和肝脏氧化应激中的潜在作用。
在本研究中，将0.25%、0.5%和0.75%剂量的ATX与高脂饮食（HFD）一起口服给予小鼠，以研究ATX在调节肝脏脂质代谢和肠道微生物群中的作用。研究表明，ATX剂量依赖性地降低体重、脂滴形成、肝脏甘油三酯，并改善肝脏脂肪变性和氧化应激。0.75%的ATX改变了34种与肝脏胆固醇和脂肪酸代谢相关的脂质代谢物水平，这可能与脂肪生成相关基因的下调和胆汁酸生物合成相关基因的上调有关。结果还显示，ATX通过显著抑制与肥胖相关的微生物生长，同时促进有益微生物的生长，减轻了HFD诱导的肠道微生物群失调。
研究结果表明，饮食中的ATX可能通过调节肠-肝轴特性来预防肝脏脂肪变性和氧化应激的发展，降低代谢疾病的风险。
