诱导多能干细胞技术在血液疾病研究中的应用。

Li Mailin, Cascino Pasquale, Ummarino Simone, Di Ruscio Annalisa

Department of Translational Medicine, University of Eastern Piedmont, Novara 28100, Italy.

Cells. 2017 Mar 8;6(1):7. doi: 10.3390/cells6010007.

The burst of reprogramming technology in recent years has revolutionized the field of stem cell biology, offering new opportunities for personalized, regenerative therapies. The direct reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) has provided an invaluable tool to study and model a wide range of human diseases. Here, we review the transforming potential of such a strategy in research and in therapies applicable to the hematology field.

近年来重编程技术的突破彻底改变了干细胞生物学领域，为个性化的再生疗法带来了新机遇。将体细胞直接重编程为诱导多能干细胞（iPSC）为研究和模拟多种人类疾病提供了一项极为宝贵的工具。在此，我们综述这种策略在血液学领域的研究及适用疗法中的变革潜力。