Ng Roy Chun-Laam, Chan Koon-Ho
Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Research Center of Heart, Brain, Hormone and Healthy Aging, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Int J Mol Sci. 2017 Mar 9;18(3):592. doi: 10.3390/ijms18030592.
The adipocyte-secreted protein adiponectin (APN) has several protective functions in the peripheral tissues including insulin sensitizing, anti-inflammatory and anti-oxidative effects that may benefit neurodegenerative diseases such as Alzheimer's disease (AD). In addition, dysregulation of cerebral insulin sensitivities and signaling activities have been implicated in AD. Emerging insights into the mechanistic roles of adiponectin and AD highlight the potential therapeutic effects for AD through insulin signaling.
脂肪细胞分泌的蛋白质脂联素（APN）在外周组织中具有多种保护功能，包括胰岛素增敏、抗炎和抗氧化作用，这些作用可能对诸如阿尔茨海默病（AD）等神经退行性疾病有益。此外，脑胰岛素敏感性和信号传导活性的失调与AD有关。对脂联素和AD机制作用的新见解突出了通过胰岛素信号传导对AD的潜在治疗作用。
