Gerke D C, Crabb G A, Frewin D B
Aust Dent J. 1978 Aug;23(4):311-3. doi: 10.1111/j.1834-7819.1978.tb03529.x.
Carpules of commercially available local anaesthetic solutions containing adrenaline have been exposed to varying conditions of heat, ultra-violet and infra-red light over a period of two months. The adrenaline content in the solutions was assessed by fluorometric assay both at the commencement of study and at regular intervals over the period of exposure. Infra-red light appeared to have little or no effect on the concentration of adrenaline, while ultra-violet light, either alone or in combination with infra-red light, caused the adrenaline levels to diminish rapidly. The results suggest that the ultra-violet component of light is probably responsible for the breakdown of catecholamines in local anaesthetic solutions when these solution are stored in areas exposed to sunlight.
含有肾上腺素的市售局部麻醉溶液安瓿在两个月的时间里经历了不同的热、紫外线和红外线照射条件。在研究开始时以及暴露期间定期通过荧光测定法评估溶液中的肾上腺素含量。红外线似乎对肾上腺素浓度几乎没有影响，而紫外线单独或与红外线结合使用时，会导致肾上腺素水平迅速下降。结果表明，当这些溶液储存在暴露于阳光的区域时，光的紫外线成分可能是导致局部麻醉溶液中儿茶酚胺分解的原因。
