Burueva Dudari B, Romanov Alexey S, Salnikov Oleg G, Zhivonitko Vladimir V, Chen Yu-Wen, Barskiy Danila A, Chekmenev Eduard Y, Hwang Dennis W, Kovtunov Kirill V, Koptyug Igor V
International Tomography Center SB RAS, 3A Institutskaya Street, 630090 Novosibirsk, Russia; Novosibirsk State University, 2 Pirogova Street, 630090 Novosibirsk, Russia.
Department of Chemistry and Biochemistry, National Chung Cheng University , 168 University Road, Min-Hsiung, Chiayi 62102, Taiwan.
J Phys Chem C Nanomater Interfaces. 2017 Mar 2;121(8):4481-4487. doi: 10.1021/acs.jpcc.7b00509. Epub 2017 Feb 7.
Hyperpolarized (HP) propane produced by the parahydrogen-induced polarization (PHIP) technique has been recently introduced as a promising contrast agent for functional lung magnetic resonance (MR) imaging. However, its short lifetime due to a spin-lattice relaxation time of less than 1 s in the gas phase is a significant translational challenge for its potential biomedical applications. The previously demonstrated approach for extending the lifetime of the HP propane state through long-lived spin states allows the HP propane lifetime to be increased by a factor of ∼3. Here, we demonstrate that a remarkable increase in the propane hyperpolarization decay time at high magnetic field (7.1 T) can be achieved by its dissolution in deuterated organic solvents (acetone- or methanol-). The approximate values of the HP decay time for propane dissolved in acetone- are 35.1 and 28.6 s for the CH group and the CH group, respectively (similar values were obtained for propane dissolved in methanol-), which are ∼50 times larger than the gaseous propane value. Furthermore, we show that it is possible to retrieve HP propane from solution to the gas phase with the preservation of hyperpolarization.
通过仲氢诱导极化（PHIP）技术产生的超极化（HP）丙烷，最近已被引入作为功能性肺磁共振（MR）成像的一种有前景的造影剂。然而，由于其在气相中的自旋晶格弛豫时间小于1秒，导致其寿命较短，这对其潜在的生物医学应用来说是一个重大的转化挑战。先前已证明的通过长寿命自旋态来延长HP丙烷态寿命的方法，可使HP丙烷的寿命增加约3倍。在此，我们证明，通过将丙烷溶解在氘代有机溶剂（丙酮 - 或甲醇 -）中，可在高磁场（7.1 T）下显著增加丙烷超极化衰减时间。溶解在丙酮 - 中的丙烷，其CH基团和CH基团的HP衰减时间近似值分别为35.1秒和28.6秒（溶解在甲醇 - 中的丙烷也获得了类似值），这比气态丙烷的值大~50倍。此外，我们表明可以将HP丙烷从溶液中回收至气相，并保持超极化状态。
