Sawada M, Carlson J C
Department of Biology, University of Waterloo, Ontario, Canada.
Mech Ageing Dev. 1987 Nov;41(1-2):125-37. doi: 10.1016/0047-6374(87)90057-1.
The free radical theory of aging was examined by measuring the formation of superoxide radical (SOR) and the level of lipid peroxides in various tissues of the aging rat. A significant increase in SOR production was seen in mitochondria prepared from the brain and the heart as rats aged. An elevation in the level of lipid peroxidation was also found in whole tissue homogenates of the brain and the liver. Vitamin E concentrations in the blood rose rapidly in young rats and remained steady except for a non significant drop in old animals. These results suggest that age-related degeneration of various tissues in the rat may be due to a rise in free radical production in the mitochondria.
通过测量衰老大鼠不同组织中超氧阴离子自由基（SOR）的形成以及脂质过氧化物的水平，对衰老的自由基理论进行了研究。随着大鼠衰老，从大脑和心脏制备的线粒体中SOR生成显著增加。在大脑和肝脏的全组织匀浆中也发现脂质过氧化水平升高。幼鼠血液中的维生素E浓度迅速上升，并保持稳定，只是老年动物有不显著的下降。这些结果表明，大鼠各种组织的年龄相关性退化可能是由于线粒体中自由基产生增加所致。
