Meital Lara T, Sandow Shaun L, Calder Philip C, Russell Fraser D
Inflammation and Healing Research Cluster, School of Health and Sport Sciences, University of the Sunshine Coast, Queensland, Australia.
Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK.
Prostaglandins Leukot Essent Fatty Acids. 2017 Mar;118:1-9. doi: 10.1016/j.plefa.2017.02.001. Epub 2017 Feb 10.
Abdominal aortic aneurysm (AAA) is an inflammatory disease associated with macrophage accumulation in the adventitia, oxidative stress, medial elastin degradation and aortic dilation. Progression of AAA is linked to increased risk of rupture, which carries a high mortality rate. Drug therapies trialled to date lack efficacy and although aneurysm repair is available for patients with large aneurysm, peri-surgical morbidity and mortality have been widely reported. Recent studies using rodent models of AAA suggest that long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) and their metabolites can moderate inflammation and oxidative stress perpetuated by infiltrating macrophages and intervene in the destruction of medial elastin. This review examines evidence from these animal studies and related reports of inhibition of inflammation and arrest of aneurysm development following prophylactic supplementation with LC n-3 PUFAs. The efficacy of LC n-3 PUFAs for management of existing aneurysm is unclear and further investigations involving human clinical trials are warranted.
腹主动脉瘤（AAA）是一种炎症性疾病，与外膜巨噬细胞积聚、氧化应激、中膜弹性蛋白降解及主动脉扩张相关。AAA的进展与破裂风险增加有关，破裂的死亡率很高。迄今为止试验的药物疗法缺乏疗效，虽然对于大动脉瘤患者可进行动脉瘤修复，但围手术期发病率和死亡率已有广泛报道。最近使用AAA啮齿动物模型的研究表明，长链ω-3多不饱和脂肪酸（LC n-3 PUFAs）及其代谢产物可减轻浸润巨噬细胞持续存在的炎症和氧化应激，并干预中膜弹性蛋白的破坏。本综述审视了这些动物研究的证据以及关于预防性补充LC n-3 PUFAs后炎症受到抑制和动脉瘤发展停滞的相关报告。LC n-3 PUFAs用于治疗现有动脉瘤的疗效尚不清楚，有必要开展涉及人类临床试验的进一步研究。
