El-Ghazely M H, Mahmoud W H, Atia M A, Eldip E M
Plastic, Reconstructive Surgery and Burns Department, Tanta Faculty of Medicine, Tanta, Egypt.
Ann Burns Fire Disasters. 2016 Dec 31;29(4):268-272.
Oral probiotic administration has been advocated for treatment and prevention of a diverse range of disorders. This study was undertaken to evaluate the effect of probiotic supplementation on outcome of pediatric post-burn patients. Forty thermally-injured pediatric patients with total body surface burns between 20-50% and depth between 5-10% were randomized in a prospective, double-blind, controlled clinical trial into two even groups: probiotic group (n=20), who received probiotic preparations, and placebo control group (n=20). Clinical outcomes, including GIT tolerance, incidence of infection, need for grafting, length of hospital stay and mortality were recorded. Laboratory measurements of serum CRP, serum albumin, serum IgA and total lymphocyte count were done upon admission and on days 4, 7 and 14. There were no significant differences between the groups regarding age (3.67 ± 0.67 vs. 3.56 ± 0.73), sex, %BSA (34.5 ± 1.96 vs. 33.9 ± 1.82) and %deep burns (6.95 ± 0.34 vs. 7.25 ± 0.39). Frequency of diarrhea (3 vs. 9), need for grafting (2 vs. 8) and length of hospital stay (17.25 ± 0.5 days vs. 21.9 ± 2.2 days) were significantly lower in the probiotic group (p=0.038, p=0.028 and p=0.044, respectively). A trend towards a decrease in incidence of infections (7 vs. 12) was noted in the probiotic group (p=0.113). There was no mortality in our series. There was improvement in the patients' overall outcome related to wound healing and length of hospital stay following the use of probiotics. However, their effects on infectious morbidity and mortality remain unclear and require further investigation.
口服益生菌已被提倡用于治疗和预防多种疾病。本研究旨在评估补充益生菌对小儿烧伤患者预后的影响。40名全身烧伤面积在20%-50%、深度在5%-10%的热损伤小儿患者，在前瞻性、双盲、对照临床试验中被随机分为两组：益生菌组（n=20），接受益生菌制剂；安慰剂对照组（n=20）。记录临床结局，包括胃肠道耐受性、感染发生率、植皮需求、住院时间和死亡率。入院时以及第4、7和14天进行血清CRP、血清白蛋白、血清IgA和总淋巴细胞计数的实验室检测。两组在年龄（3.67±0.67 vs. 3.56±0.73）、性别、烧伤面积百分比（34.5±1.96 vs. 33.9±1.82）和深度烧伤百分比（6.95±0.34 vs. 7.25±0.39）方面无显著差异。益生菌组腹泻频率（3例 vs. 9例）、植皮需求（2例 vs. 8例）和住院时间（17.25±0.5天 vs. 21.9±2.2天）显著更低（分别为p=0.038、p=0.028和p=0.044）。益生菌组感染发生率有下降趋势（7例 vs. 12例）（p=0.113）。本系列中无死亡病例。使用益生菌后，患者在伤口愈合和住院时间方面的总体预后有所改善。然而，它们对感染性发病率和死亡率的影响仍不明确，需要进一步研究。
