Pringsheim Tamara
Department of Clinical Neurosciences, Psychiatry, Pediatrics and Community Health Sciences, Mathison Centre for Mental Health Research and Education, University of Calgary, 3280 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada.
Child Psychiatry Hum Dev. 2017 Dec;48(6):960-966. doi: 10.1007/s10578-017-0718-z.
While attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder have been shown to have major impacts on quality of life in individuals with Tourette syndrome, there is comparatively little data on how the presence of these comorbidities influence tic severity and treatment. 114 children (mean age 10.25 years) were extensively clinically phenotyped at a single specialty clinic. While there was no difference in Yale Global Tic Severity Scale (YGTSS) scores in children with versus without ADHD, children with obsessive compulsive behaviors had significantly higher YGTSS scores (p = 0.008). There was a significant correlation between YGTSS scores and age (r = 0.344, p < 0.001). Children with ADHD were more likely to be treated for their tics within the first two years of diagnosis (OR 3.51, p = 0.009). As tic severity does not appear to be greater in children with ADHD, this association may relate to greater overall psychosocial impairment in children with this comorbidity.
虽然注意力缺陷多动障碍（ADHD）和强迫症已被证明对抽动秽语综合征患者的生活质量有重大影响，但关于这些共病的存在如何影响抽动严重程度和治疗的数据相对较少。114名儿童（平均年龄10.25岁）在一家专科诊所进行了全面的临床表型分析。虽然患有和未患有ADHD的儿童在耶鲁全球抽动严重程度量表（YGTSS）评分上没有差异，但有强迫行为的儿童YGTSS评分显著更高（p = 0.008）。YGTSS评分与年龄之间存在显著相关性（r = 0.344，p < 0.001）。患有ADHD的儿童在诊断后的头两年内更有可能接受抽动治疗（OR 3.51，p = 0.009）。由于患有ADHD的儿童抽动严重程度似乎并不更高，这种关联可能与患有这种共病的儿童总体心理社会损害更大有关。
