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菲啶酮类化合物的合成策略。

Synthetic Strategies in the Preparation of Phenanthridinones.

机构信息

Organic Chemistry Department, Science Faculty, RUDN University, Miklukho-Maklaya St., 6, 117198 Moscow, Russia.

Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001 Leuven, Belgium.

出版信息

Molecules. 2021 Sep 13;26(18):5560. doi: 10.3390/molecules26185560.

DOI:10.3390/molecules26185560
PMID:34577030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8466741/
Abstract

Phenanthridinones are important heterocyclic frameworks present in a variety of complex natural products, pharmaceuticals and displaying wide range of pharmacological actions. Its structural importance has evoked a great deal of interest in the domains of organic synthesis and medicinal chemistry to develop new synthetic methodologies, as well as novel compounds of pharmaceutical interest. This review focuses on the synthesis of phenanthridinone scaffolds by employing aryl-aryl, -aryl, and biaryl coupling reactions, decarboxylative amidations, and photocatalyzed reactions.

摘要

菲啶酮是存在于多种复杂天然产物、药物中的重要杂环骨架，具有广泛的药理作用。其结构重要性激发了有机合成和药物化学领域的极大兴趣，以开发新的合成方法以及具有药物应用前景的新型化合物。本文综述了通过芳基-芳基、芳基和联芳基偶联反应、脱羧酰胺化和光催化反应合成菲啶酮骨架的方法。

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