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Risk of incident clinical diagnosis of Alzheimer's disease-type dementia attributable to pathology-confirmed vascular disease.归因于病理确诊的血管疾病的阿尔茨海默病型痴呆临床诊断事件风险。
Alzheimers Dement. 2017 Jun;13(6):613-623. doi: 10.1016/j.jalz.2016.11.003. Epub 2016 Dec 23.
2
TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementia.TDP-43分期、混合性病变与临床阿尔茨海默病型痴呆
Brain. 2016 Nov 1;139(11):2983-2993. doi: 10.1093/brain/aww224.
3
Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study.老年人群中脑血管疾病与阿尔茨海默病性痴呆及认知功能的关系：一项横断面研究
Lancet Neurol. 2016 Aug;15(9):934-943. doi: 10.1016/S1474-4422(16)30029-1. Epub 2016 Jun 14.
4
Trends in autopsy-verified dementia prevalence over 29 years of the Hisayama study.久山町研究29年间经尸检确诊的痴呆症患病率趋势。
Neuropathology. 2016 Aug;36(4):383-7. doi: 10.1111/neup.12298. Epub 2016 Mar 14.
5
Impact of interventions to reduce Alzheimer's disease pathology on the prevalence of dementia in the oldest-old.减少阿尔茨海默病病理改变的干预措施对高龄老人痴呆症患病率的影响。
Alzheimers Dement. 2016 Mar;12(3):225-32. doi: 10.1016/j.jalz.2016.01.004. Epub 2016 Feb 17.
6
Neuropathologic comorbidity and cognitive impairment in the Nun and Honolulu-Asia Aging Studies.修女研究与檀香山-亚洲老年研究中的神经病理学合并症与认知障碍
Neurology. 2016 Mar 15;86(11):1000-8. doi: 10.1212/WNL.0000000000002480. Epub 2016 Feb 17.
7
Higher brain BDNF gene expression is associated with slower cognitive decline in older adults.大脑中较高的脑源性神经营养因子（BDNF）基因表达与老年人认知能力下降较慢有关。
Neurology. 2016 Feb 23;86(8):735-41. doi: 10.1212/WNL.0000000000002387. Epub 2016 Jan 27.
8
Age, Sex, and APOE ε4 Effects on Memory, Brain Structure, and β-Amyloid Across the Adult Life Span.年龄、性别和APOE ε4对成年期记忆、脑结构及β淀粉样蛋白的影响。
JAMA Neurol. 2015 May;72(5):511-9. doi: 10.1001/jamaneurol.2014.4821.
9
Residual decline in cognition after adjustment for common neuropathologic conditions.在对常见神经病理状况进行校正后认知功能的残余下降。
Neuropsychology. 2015 May;29(3):335-43. doi: 10.1037/neu0000159. Epub 2014 Dec 15.
10
Potential for primary prevention of Alzheimer's disease: an analysis of population-based data.阿尔茨海默病的一级预防潜力：基于人群数据分析。
Lancet Neurol. 2014 Aug;13(8):788-94. doi: 10.1016/S1474-4422(14)70136-X.

混合病理学与神经储备：复杂性对阿尔茨海默病药物研发的影响。

Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery.

作者信息

Bennett David A

机构信息

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.

出版信息

PLoS Med. 2017 Mar 14;14(3):e1002256. doi: 10.1371/journal.pmed.1002256. eCollection 2017 Mar.

DOI:10.1371/journal.pmed.1002256
PMID:28291788
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5349649/
Abstract

In a Perspective, David Bennett makes a case for neural reserve to be considered as a therapeutic endpoint in clinical trials for dementia.

摘要

在一篇《观点》文章中，大卫·贝内特提出了将神经储备作为痴呆症临床试验治疗终点的理由。