混合病理学与神经储备：复杂性对阿尔茨海默病药物研发的影响。
Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery.
作者信息
Bennett David A
机构信息
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.
出版信息
PLoS Med. 2017 Mar 14;14(3):e1002256. doi: 10.1371/journal.pmed.1002256. eCollection 2017 Mar.
Abstract
In a Perspective, David Bennett makes a case for neural reserve to be considered as a therapeutic endpoint in clinical trials for dementia.
摘要
在一篇《观点》文章中，大卫·贝内特提出了将神经储备作为痴呆症临床试验治疗终点的理由。
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Alzheimers Dement. 2017 Jun;13(6):613-623. doi: 10.1016/j.jalz.2016.11.003. Epub 2016 Dec 23.
2
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3
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