Cardoso Marcio Vivan, Chaudhari Amol, Yoshihara Kumiko, Mesquita Marcelo Ferraz, Yoshida Yasuhiro, Van Meerbeek Bart, Vandamme Katleen, Duyck Joke
Int J Oral Maxillofac Implants. 2017 Mar/Apr;32(2):282-290. doi: 10.11607/jomi.5074.
To investigate the effect of coating a titanium implant surface with a phosphorylated exopolysaccharide, pullulan, on the peri-implant bone formation and implant osseointegration.
Implants were placed in the skull bone of 12 domestic pigs and healed for 1 or 3 months. Osseointegration of (un)coated implants was evaluated by quantitative histology (peri-implant bone fraction [BF] and bone-to-implant-contact [BIC]). The Wilcoxon-Mann-Whitney test with α = .05 was used to statistically compare BF and BIC of the coated and uncoated implants.
Significantly more BF was observed surrounding pullulan-coated implants compared with uncoated implants (P < .05) and for both healing periods (P < .05). BIC was positively affected by the exopolysaccharide coating, with significantly more BIC after the 3-month healing period compared with the uncoated implant (P < .05). Furthermore, BIC remained stable over time for the coated implants, while it significantly decreased for the uncoated ones (P < .05).
These findings reveal the capacity of functionalizing the titanium implant surface with phosphorylated pullulan to improve the mineralization of the implant-bone interface.
研究用磷酸化胞外多糖普鲁兰多糖包被钛种植体表面对种植体周围骨形成和种植体骨整合的影响。
将种植体植入12头家猪的颅骨中，愈合1或3个月。通过定量组织学（种植体周围骨分数[BF]和骨与种植体接触[BIC]）评估（未）包被种植体的骨整合情况。采用α = 0.05的Wilcoxon-Mann-Whitney检验对包被和未包被种植体的BF和BIC进行统计学比较。
与未包被种植体相比，在两个愈合期内，普鲁兰多糖包被种植体周围均观察到显著更多的BF（P < 0.05）。胞外多糖包被对BIC有积极影响，3个月愈合期后，包被种植体的BIC显著多于未包被种植体（P < 0.05）。此外，包被种植体的BIC随时间保持稳定，而未包被种植体的BIC则显著下降（P < 0.05）。
这些发现揭示了用磷酸化普鲁兰多糖对钛种植体表面进行功能化处理以改善种植体-骨界面矿化的能力。
