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在阿尔茨海默病高危人群中，心肺适能、海马体积与情景记忆之间的关系。

Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer's disease.

机构信息

William S. Middleton Memorial Veterans Hospital Madison WI USA; Department of Kinesiology University of Wisconsin School of Education Madison WI USA.

Geriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison WI USA; Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison WI USA; Wisconsin Alzheimer's Institute University of Wisconsin School of Medicine and Public Health Madison WI USA.

出版信息

Brain Behav. 2017 Feb 17;7(3):e00625. doi: 10.1002/brb3.625. eCollection 2017 Mar.

DOI:10.1002/brb3.625
PMID:28293467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5346514/
Abstract

INTRODUCTION

Cardiorespiratory fitness (CRF) has been shown to be related to brain health in older adults. In individuals at risk for developing Alzheimer's disease (AD), CRF may be a modifiable risk factor that could attenuate anticipated declines in brain volume and episodic memory. The objective of this study was to determine the association between CRF and both hippocampal volume and episodic memory in a cohort of cognitively healthy older adults with familial and/or genetic risk for Alzheimer's disease (AD).

METHODS

Eighty-six enrollees from the Wisconsin Registry for Alzheimer's Prevention participated in this study. Participants performed a graded maximal exercise test, underwent a T-1 anatomical magnetic resonance imaging scan, and completed the Rey Auditory Verbal Learning Test (RAVLT).

RESULTS

There were no significant relationships between CRF and HV or RAVLT memory scores for the entire sample. When the sample was explored on the basis of gender, CRF was significantly associated with hippocampal volume for women. For men, significant positive associations were observed between CRF and RAVLT memory scores.

SUMMARY

These results suggest that CRF may be protective against both hippocampal volume and episodic memory decline in older adults at risk for AD, but that the relationships may be gender specific.

摘要

简介

心肺适能（CRF）已被证明与老年人的大脑健康有关。在有患阿尔茨海默病（AD）风险的个体中，CRF 可能是一种可改变的风险因素，可以减缓预期的脑容量和情景记忆下降。本研究的目的是确定在具有阿尔茨海默病（AD）家族和/或遗传风险的认知健康老年人队列中，CRF 与海马体积和情景记忆之间的关联。

方法

威斯康星州阿尔茨海默病预防登记处的 86 名参与者参加了这项研究。参与者进行了分级最大运动测试，进行了 T1 解剖磁共振成像扫描，并完成了 Rey 听觉言语学习测试（RAVLT）。

结果

整个样本中，CRF 与 HV 或 RAVLT 记忆评分之间没有显著关系。当根据性别对样本进行探索时，CRF 与女性的海马体积显著相关。对于男性，CRF 与 RAVLT 记忆评分之间存在显著的正相关关系。

总结

这些结果表明，CRF 可能对 AD 高危老年人的海马体积和情景记忆下降具有保护作用，但这种关系可能具有性别特异性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6020/5346514/e1910c6c66e2/BRB3-7-e00625-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6020/5346514/263f0d26ee4c/BRB3-7-e00625-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6020/5346514/558274b2a792/BRB3-7-e00625-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6020/5346514/4eadd12fae56/BRB3-7-e00625-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6020/5346514/3e2a1e8c0130/BRB3-7-e00625-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6020/5346514/e4107b0696dd/BRB3-7-e00625-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6020/5346514/ec8d87fa6446/BRB3-7-e00625-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6020/5346514/e1910c6c66e2/BRB3-7-e00625-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6020/5346514/263f0d26ee4c/BRB3-7-e00625-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6020/5346514/558274b2a792/BRB3-7-e00625-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6020/5346514/4eadd12fae56/BRB3-7-e00625-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6020/5346514/3e2a1e8c0130/BRB3-7-e00625-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6020/5346514/e4107b0696dd/BRB3-7-e00625-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6020/5346514/ec8d87fa6446/BRB3-7-e00625-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6020/5346514/e1910c6c66e2/BRB3-7-e00625-g007.jpg

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